- Policeman vs. Fireman on YouTube has the ongoing "friendship" between Butt-Monkey Policeman Perry and chick magnet Fireman Jake as the main subject matter. Hilarity Ensues.
- The Jake & Amir sketches from College Humor are built on this trope. Amir is usually the one who is annoying (and often stalking) Jake. However, they occasionally switch roles.
- Matt and Dusty from... well, Matt 'n' Dusty, strongly invoke this whenever they talk to each other. Even by themselves, Dusty is a Jerkass to everyone and Matt occasionally gives off some passive aggressive vibes.
- The Tipping Forties crew are a circle of jerks but have been friends for a good time. See their Mario Party LP.
- The Switcher's Two Best Friends Play series (viewable here). Only genuinely good friends could hate each other that much.
- The Wisenheimer's Podcast between Yotam Perel (Lazymuffin) and Max Gilardi (hotdiggedydemon) thrives on this trope.
- Voldemort and Quirrel from A Very Potter Musical. Harry and Ron also tend to act this way toward Hermione, but Ron, of course, is in love with her and Harry considers her to be like a sister. Ron also fits with his little sister, Ginny. To Draco:She may be a pain in the ass, okay? But she's my pain in the ass.
- Black Jack Justice
- Not an episode goes by where Trixie and Jack don't bicker and threaten each other at a pace that would make the Gilmore Girls jealous. They even have some pat, oft-repeated gibes for when they're tired, such as "You miss me?" "With every bullet so far". Yet rarely, if ever, does their partnership seem to suffer for it as the two make a stellar team.
- Police Lieutenant Victor Sabien fits this bill with both of them. In fact, when an episode opens with Vic walking in and not insulting them, that's their first, best clue that he's truly upset.
- Jack and Freddie the Finger have a relationship of this sort. It's a little softer and more gentle than the rest of the cast, as Jack and Freddy go back a long way.
- Basically every character Red Hood encounters during the course of Hero House.
- Lewis Brindley and Simon Lane from the Yogscast, especially in the Minecraft series where they're regularly hitting one another with diamond swords, pushing each other off blocks, and being generally snarky... And the rest of the time they're calling each other pal, helping each other through fear inducing challenges, and making Slash Fic jokes. Woe betide anyone who unites them against a common enemy.
- In The Little Wood and So Totally Toby have a similar relationship. The two abuse and snark at one another constantly, with Martyn dishing out most of it, but they're good friends.
- Speaking of Martyn Littlewood, he has this sort of relationship with both Strippin and Sparkles* as part of the "Dream Team". They all enjoy hanging around together, but Sparkles* spends half his time snarking at the others, while Strippin gets a lot of the flak.
- Hat Films have this sort of dynamic with one another, constantly abusing one another, killing each other in games for their amusement and snarking at each other. They're all really good friends in spite of this. They also love collaborating with Sips, Turpster and Lewis Brindley, but their competitive matches in Garry's Mod, Trouble in Terrorist Town, Prop Hunt and The Hidden are very profane.
- Sips gets on well with Sjin, but the former spends most of his time outright abusing the latter. He also gets on well with Hat Films despite their collaborative videos and constant swearing at each other.
- The title characters of Xolga And Mr Toko practically are this trope. Every time Mr.Toko wants to help Xolga in some way, Xolga being his Jerkass Woobie self, constantly insults Mr.Toko and most of the time doesn't take him seriously. But despite their differences, they seem to really care for each other.
- The group of Let's Players known as the Freelance Astronauts fall into this territory quite often in their videos - likely aided by the fact that they seem to have more or less grown up around each other, and have had years to get used to each of them treating the others this way.
- Chuggaaconroy and ProtonJon in The Runaway Guys are consistently trying to kill one another [in game of course] and constantly make jokes at one another's expense, but it's clear that they do genuinely like each other.
- Ian and Anthony of Smosh. They call each other horrible names, smack each other around, and sometimes just flat out kill each other. And yet they're still clearly best friends.
- Frollo and Gaston from The Frollo Show. They're the best of friends and will fight to the death for one another, but can't help but dick each other over at every opportunity.
- Pretty much everyone from Achievement Hunter is this, notable examples are Jack and Geoff, and Michael and Gavin.
- In RWBY, Weiss and Ruby end up with some shades of this towards the end of Volume 1. Establishing moment being the combat skirt low-five. A season later, all it takes is a shared glance at each other for Weiss to know what to do to prevent the team and Oobleck from dying in a fiery crash.
- There's also an Evil Counterpart in the form of Mercury and Emerald. Even though the two can bicker with one another, they still work effectively as a team in and out of battle.
- Josh Hadley and Scott Murray, hosts of Lost in the Static; on some shows, they seem close to breaking out into a fist fight. There were a few episodes at one point, in fact, where Scott took some time off, mainly to keep that from actually happening. Unfortunately, the best buds part is now over, after Scott got busted for possessing child pornography and Josh cut all ties with him.
- Coffee Talk and Sombra from Ask King Sombra. While Sombra may be largely self-centered, and their current relationship may hinging primarily on Coffee Talk blackmailing Sombra into behaving, he does care about Coffee Talk a little, as he immediately went off in search of her after he was revived, getting himself captured by Crystal Wolves in order to find her.
- Mark and Cory of the Lets Play Modestly ProphItic jump at any chance they have to insult, berate and screw each other over while recording, but off camera (off mic?) they are extremely close friends.
- Ben Croshaw aka Yahtzee and his one-time bouncer, Gabriel Morton's relationship, or at how they're least depicted in their Let's Plays (or Let's Drown Out due to its podcast style). Gabriel's a recovering alcoholic—a source of much chortling from the oft-soused, self-medicating Yahtzee — who "takes up space" at Yahtzee's bar and doesn't order any drinks, is prone to big pontifical statements, and seemingly dislikes any genre of game that doesn't involve "hit-y" things. Yahtzee has a competitive streak, compelling him to dissect everything Gabriel says and mock his shortcomings, such as his weight and investment in worthless history courses. It's apparently become so vitriolic that, in the beginning of 'Let's Drown Out Sims 3' video, they have to explain that they are best friends with each other and essentially told their viewers to go get friends in order to understand the subtlety of human interaction. Yahtzee also pointed out that if he openly insulted you, it means that he is comfortable enough with you to do so whereas if he's unnaturally polite, it meant he's gotten sick of you."It's because I'm comfortable enough to call you a fat, sweaty bitch that indicates my high esteem for you."
"Yeah, y'know, and I call you vaguely-autistic shut-in nutbar."
- If you did not know STAR__ by his 'Sniper Stomper' video, you may have known him from his famous trilogy (Ruiner of Fun, Jerma is Mad pt 2 and part 3) where he made his his best bud, Jerma985, mad as hell and sending him into the vulgar humorous rage while STAR_ effortlessly outplay him time and time again and it extends beyond those videos. It's still clear that these two are the best buds, seeing that they keep playing with each other.
- The bears of Where the Bears Are are very close friends, though it's sometimes hard to tell given how Nelson and Reggie snipe at each other and how both belittle Wood.
- In The Sonic Amigos, Sonic constantly abuses Tails, but they seem to be good friends regardless.
- Gunny and Rhino from The Damn Few.
- Golgotha from Noob acts this way towards everyone she considers allies or friends. Nobody is giving the vitriol back, but only the stupidest characters are oblivious to it while most just understand that this is her way of addressing people and interact with her normally.
- All of the Sidemen, considering they have natural knacks for bantering, which is more than visible in their videos together. However, there are moments where they do genuinely get along.
- Scanlan has a habit of annoying the hell out of Tiberius in Critical Role, but episode 16 has them trading their headgear as Tiberius thought it would benefit them both. Out-of-universe, Matt teases Orion quite a bit despite their solid friendship.
- Steve And Carlos have a version of this, with Carlos repeatedly threatening to stab Steve and Steve insulting Carlos repeatedly. It's to the point you can hardly tell that they are indeed friends.
- Pretty much the defining trait of the Reds and Blues' friendship with each other in the later seasons.
- Linkara and his Robot Buddy Pollo from Atop the Fourth Wall are friends—but Pollo isn't above asking for embarrassing favors. When Pollo helped save Linkara from Mechkara, who is really Pollo from an alternate universe wearing his Linkara's skin, his favor involves being the host of an episode where he goes on a rant against Garth Ennis. Likewise, when Pollo comes back in the review of the comic adaptation of Star Trek III: The Search for Spock (having "died", fittingly, during the review of IDW's adaptation of Star Trek II: The Wrath of Khan), he wants to review the first issue of Red Hood and the Outlaws with Linkara in Pollo's place. When Linkara points out that (at the time), it didn't fall under his cutoff date, Pollo reveals that he has access to Linkara's bank accounts and thus forces Linkara to comply.
- Lyon and Valerian of There is no GATE; we did not fight there originally despised each other, due to Lyon finding Valerian as stuck up and dishonest and Valerian thinking of Lyon as a barbaric idiot, though he held his tongue due to his respect for Kytheus. After the interlude *Vale and Ly's Excellent Adventure*, they've evolved into this trope, with Lyon insulting Valerian as usual and Valerian no longer holding back his true thoughts.
- In Sanders Sides, the Sides easily qualify (except Patton, who doesn't have a mean bone in his body). They all deeply care for Thomas and consider themselves best friends, but they often get caught up in petty infighting, arguments, and pranks. Between Logan's haughtiness, Roman's self-centered nature, and Virgil's snarkiness, it's a miracle anything gets done.
- In Soviet Womble's clan, this is the default way anyone interacts with anyone else, but the prize has to go to Womble and Cyanide, whose constant insulting and trolling of each other hasn't stopped them teaming up for lots and lots and lots of videogames.
- Amoridere seems to have a fondness of these and a notable example would be Toki and Doki, her twin sister, however, downplayed. They have their moments of feuding but, regardless, they will come through for each other. The same thing would go for Toki and her friends, as she cares for them but doesn't hesitate to brawl with them or beat them up, either.
- Dragon Ball Abridged: Yamcha and Tien are portrayed this way, constantly shooting barbs at one another, but ultimately fighting together when it counts. Spelled out in episode 60, when they believe that they may die against Perfect Cell:Yamcha: Hey, Tien, if this is really the end, I-
Tien: If you say "I love you", I swear to God-!
Yamcha: Actually, I was going to say you're the biggest asshole I know.
Yamcha: ...you're also my best friend.
Tien: ...so are you, man.
- The Case of the Gilded Lily gives us Fig Wineshine and Ford Phillips. She takes to him right away and wants to be crime-solving partners, which he rejects the entire time, only for The Stinger to reveal that that's exactly what happens.
Vitriolic Best Buds / Web Original