In the game, Itarou meets five girls: Matsuri Jasmine, Mihomi Hydrangea, Ayume Daffodil, Moeko Ivy, and Nenene Anemone, and attempts to start a relationship with one of them. However, as the days pass, he will learn that his chosen girl is not what she seems...
In 2018, Charon released a Japanese-only spinoff game titled Mihomi Dream, focusing on Mihomi's past.
Another spinoff game was released in September 2019 titled Nenene Noble, focusing on Nenenes past instead.
Starting in August 2019, an episodic sequel, Dice Psycho, was released in Japanese. All six episodes have been completed as of December 2019.
Menherafflesia contains examples of:
- Abusive Parents: Mihomi is abused by her stepfather for being the child of her mother's first marriage.
- Arranged Marriage: Nenene is stuck in one. She doesn't appreciate it, and tries to get Itarou to elope with her. It... doesn't end well.
- Ascended Extra: The Stinger shows a young girl named Misa, who appears in another game called Paranoia and is the mascot of the Charon universe.
- Color Motif: Matsuri has red, Mihomi has blue, Ayume has yellow, Moeko has green, and Nenene has purple.
- Death Seeker: Matsuri has always been one, despite her Genki Girl facade. The flashback in her Happy End reveals that she's been waiting to find the right person who will kill her.
- Downer Ending: The Bad Ends all end with someone dying. The Happy Ends aren't much better.
- Driven to Suicide: Every girl except for Ayume in their Happy Ends.
- Flower Motif:
- Each girl is associated with (and named after) a type of flower.
- The game itself uses rafflesias as a motif.
- Freudian Excuse: All of the girls have some sort of trauma that causes their violent behavior.
- Genki Girl: Matsuri. Except not really.
- Last-Second Ending Choice: Whether you get the Happy End or Bad End in each route is always determined by a single choice, which is conveniently displayed in red.
- Multiple-Choice Past: Itarou's background differs depending on which route you're playing.
- Multiple Endings: Each route has two endings: a Happy End and a Bad End. There is also the True End route, "Flowerbed", which can be unlocked with a password after reaching all of the Happy Ends.
- Paper-Thin Disguise: "Kurara" is obviously just Moeko in a costume. For some reason, Itarou doesn't realize this until she tells him.
- Portmantitle: The game's title is a portmanteau of menhera, a Japanese slang term for the mentally ill, and rafflesia, a type of flower.
- Serial Killer: Ayume is one, and has been since her entire family was murdered when she was a child.
- Nenene became one after killing the upperclassmen who bullied Itarou.
- Spiritual Successor: To Charon's previous game, Mix Ore, due to the Gamebook elements.
- Stalker with a Crush: Matsuri and Mihomi both stalk Itarou.
- Yandere: Most of the girls turn out to be this. It is a Charon game, after all.
- You Gotta Have Blue Hair: All of the girls except for Ayume have unnatural hair colors which match their Color Motifs.