The Dreamworks Animation film Megamind had a tie-in video game that continued the storyline. It was followed by Megamind: Mega Team Unite.
- Big Bad: Blue Titan returns as the founder of the Doom Syndicate, who are causing chaos in Metro City.
- Canon Foreigner: A downplayed example. Destruction Worker, Psycho Delic and Hot Flash, the non-Titan bosses and Doom Syndicate members, originated from an early version of the film.
- Co-Op Multiplayer: In the game, the second player can play as a Brainbot.
- Down the Drain: The Psycho Delic levels take place in the sewers.
- Drop-In-Drop-Out Multiplayer: The second player can join in and quit at any time.
- Mission Control: Minion gives hints to Megamind throughout the game via his communicator.
- Mook: Destruction Worker, Psycho Delic and Hot Flash have their own brand of mooks.
- Multi-Platform: The game is made for the PS3, Xbox 360, Nintendo DS and PSP.
- It's Up to You: Megamind is required to defeat the Doom Syndicate and Blue Titan.
- Plot Coupon: Pieces of the DNA machine are found at the end of the normal levels, and beating bosses nets Blue Titan's DNA, which serve as clues to where Blue Titan is.