Two particularly talented scientists present a crystallised energy source referred to as "Visnium" to help prevent an incoming energy crisis, only for them and their energy diamond to suddenly get stolen away by Dr. Wily! Dr. Wily then proceeds to use the diamond to power up his robot army and the scientists' forcibly reprogrammed Robot Masters for world conquest. Once again, Mega Man and Bass must stop a new threat from the megalomaniacal genius.
The game features examples of the following tropes:
- Everything Fades: The gameplay footage available so far shows that the destroyed objects completely disappear from existence as soon a brief explosion effect fades.
- Flash of Pain: The gameplay footage shows that the current player character flashes white for a few seconds after getting hit.
- Shield-Bearing Mook: One of the enemies seen in the gameplay footage carries a shield, and covers himself with it whenever he's not firing his blaster. However, sustained direct hits to the shield will make him drop it, and thus render him vulnerable.
- Spread Shot: Gameplay footage shows an enemy that pops out of the ground while wearing a miner's helmet, and then fires a spread of three rock-like projectiles before retreating back underground.