Following the genocide of the Nephilim, The Charred Council sends Strife and War on a new mission to destroy various demon masters who have pledged themselves to Lucifer, as The Dark Prince intends to upset the Balance Between Good and Evil. The Horsemen duo must hunt these masters down, while gathering new information about a conspiracy brewing that may jeopardize The Council, who have been left in charge of creation.
The game provides examples of:
- Co-Op Multiplayer: Two players can take control of War and Strife through the story.
- Deadpan Snarker: Strife is a snsrky gunslinger who's not shy about being sarcastic at one's expense.
- Foil: War and Strife are this to eachother. The former is a dead serious hulk of a man with a big sword, while the latter is a snarky dual-wielding gunslinger of average height.
- Genre Shift: Genesis is a top-down Action RPG with optional co-op, while the previous Darksiders entries were Action-Adventure games with exploration.