The game is described by its creators as a "Post Apocalyptic kung fu fable", or "Kung Fu Panda with a touch of Mad Max in it". It is set in a world filled with animals who have mutated into sentient races a long time ago. Their new society centers around the great World Tree. One day, however, toxic oil came up from underground and began to poison the tree. Moreover, this weakness was sensed by five great monsters, which started to feast on the roots. It is now imperative for you to slay them all.
However,this is only a part of a larger mosaic, as there are six tribes around the tree, many with conflicting goals: for instance, only half of them are desperate to heal the World Tree to its former glory, as the other three are instead eagerly laying groundwork for their plans once it collapses. You are free to choose how you intend to interact with them, making decisions that'll significantly alter the course of the story.
Tropes seen in the preview material for Biomutant:
- Dialogue Tree: The gameplay trailer shows that the player selecting responses through a conversation wheel.
- Exploding Barrels: The large boss seen in the gameplay trailer, Rocka-Boom, throws fuel barrels at the player, with no regard for its small allies who can easily get caught up in the blast as well.
- Flunky Boss: The boss seen in the gameplay trailer, Rocka-Boom, has a bunch of small anthropomorphic rat allies on its side.
- Written Sound Effect: In the gameplay trailer, colorful words like "SMASH" and "BOOM" appear when the player delivers a sustained beat-down to an enemy.