The first Big Brain Academy game was released to promote the Nintendo DS Lite and later a sequel was released for the Wii with the option to compare scores with others around the world. This series of games gives timed quizzes and puzzles to players in an effort to determine their brain mass. Comparisons with Brain Age were inevitable but between the two, Big Brain Academy takes your mental measurements less seriously, being more focused on playful jabs at the player's expense and pushing them towards earning high scores.
- Difficulty Levels: Three difficulties are present, but it's not settable for the Wii game's multiplayer.
- Dynamic Difficulty: In the Wii version, the game's difficulty adjusts according to your current score.
- Ghost Leg Lottery: "Pathfinder" has a number of animals (more as the game gets more difficult) at the top of the screen. The player must draw one or more legs connecting the vertical lines so when the animals follow the paths downward, they all reach their partner of the same species waiting at the bottom of the screen.
- Fingerless Hands: Dr. Lobe, being a cartoony, vaguely-human-shaped thing, has hands that lack detail such as fingers.
- My Brain Is Big: Your score is determined in grams.
- Rank Inflation: Platinum Medals, which follow gold.
- Speaking Simlish: Dr. Lobe's dialogue is perfectly readable, but the sounds produced are gibberish.