- Playing Against Type: Many of Mihm's regular stable of actors are cast against type in this film.
- Douglas Sidney, who previously played two scientists, plays soldier John Baker.
- Rachel Grubb, who previously played an aggressive amazon, plays the meeker (but still feisty) waitress Leisl.
- James Norgard, who usually plays grandfatherly men, plays the Nazi mad-scientist who creates the Weresquito.
- Mike Cook, who played the kindly Dr. Edwards in several earlier films, appears as Nazi Karl Schmidt.
- Daniel Sjerven, who usually plays aggressive but heroic characters, plays Leisl's abusive suitor Eric.
- You Look Familiar:
- Cpl. John Baker is played by Mihmiverse regular Douglas Sidney, who previously played Barney Collins in The Late Night Double Feature and Dr. Collins in Attack of the Moon Zombies.
- Leisl Schmidt is played by Mihmiverse regular Rachel Grubb, who previously played Amy in The Monster of Phantom Lake and Hagra in Cave Women on Mars.
- Mihmiverse regular James Norgard, who played Dr. Gabriel in several movies, plays the role of Dr. Schramm.
- Stephanie Mihm has a cameo as the woman in the diner.
- Mihmiverse regular Daniel Sjerven plays the role of Eric, having played the reoccurring role of Captain Frehley in two earlier films among other roles.
- Mihmiverse regular Mike Cook, who played Dr. Edwards in multiple films among other roles, plays the role of Nazi Karl Schmidt.
Trivia / Weresquito: Nazi Hunter