- Actor Allusion: In "The Chateau" chapter, Sully tells Nate that the building "doesn't look old enough to be a Crusader castle. Looks more like Renaissance to me." At the game's time of release in 2011, who were Desmond Miles' two known ancestors?
- Development Gag: The shirt that Young Nathan wears is the same one he wore in the original announcement trailer for the first game, before it was changed. He also wears this shirt in Eye of Indra. Uncharted 4: A Thief's End implies it's the faded hand-me down of his older brother, Sam.
- Unintentional Period Piece: This game takes place partly in Syria and Yemen, which are both portrayed as (relatively) peaceful countries without a hint of civil war, firmly placing this game in a setting predating The Arab Spring (which actually began almost a full year before the game came out, but nothing was modified during development to reflect this). Could also double as Harsher in Hindsight, given the explosive gun battles in those locations that Drake participates in.
- What Could Have Been:
- You Look Familiar: Graham McTavish previously voiced Lazarevic, the Big Bad of Among Thieves, which helps to mask the fact that he's a good guy as Cutter in Drake's Deception.
Trivia / Uncharted 3: Drake's Deception