- Role-Ending Misdemeanor: Jeffrey Tambor quit the series in November 2017 after multiple sexual harassment allegations.
- You Look Familiar: Several actors who appeared in the flashbacks to 1994 during Season 1 appear as different characters in the flashbacks to 1933 during Season 2.
- Bradley Whitford plays Mark/Marcy in the 1990s and Magnus Hirschfield in the 1930s.
- Emily Robinson plays 12-year-old Ali in the 1990s and a young version of Maura's mother Rose in the 1930s.
- Mel Shimkovitz plays Jules, a bartender hired for Ali's Bat Mitzvah, then Jude, one of the residents of the Institute for Sexual Research.
- Michaela Watkins plays Connie, the sympathetic wife of a transvestite, and then Maura's grandmother Yetta.
Trivia / Transparent