- Ascended Fanon: Dick Grayson's Urban Legend Love Life is much less of an urban legend in the show.
- California Doubling: Set in Detroit, yet filmed in Toronto.
- Fake American:
- Fake Russian: Konstantin Kovar is played by English-French Mark Anthony Krupa.
- The Other Darrin: For some reason, several members were recast from Titans to Doom Patrol.
- Bruno Bichir doesn't reprise the Chief and instead Timothy Dalton takes over.
- Matt Bomer replaces Dwain Murphy as Negative Man.
- Jake Michaels portrays Robotman in Titans, but in this show the role is split between Brendan Fraser (who provides his voice and portrays him in his previous human form) and Riley Shanahan (who portrays him in the present).
- Production Posse: Matt Bomer, Alan Ritchson, Alan Tudyk, Sherelyn Fenn, and Marina Sitris are all DC Comics adaptation veterans.
- What Could Have Been:
- Barbara Gordon was going to be part of Titans when it was in development for TNT, as her pre-New 52 identity Oracle.
- Warner Bros. had wanted a Doom Patrol movie back in 2006, and yet nothing ever came of it. After many years, Doom Patrol will now be refit for web television.
- Kelsey Grammer was in major talks to play the Chief, but for unstated reasons the deal didn't go through, and Timothy Dalton was cast instead.
Trivia / Titansverse