Blooper: "S.O.S. Part 2" has Gordon launch Thunderbird 4 from Tracy Island. When we are shown the launch bay, Thunderbirds 3 and Shadow are shown to be absent even though no one else has left Tracy Island, and are both shown in the hangar a few minutes later.
Sylvia Anderson cameos as Lady Sylvia Creighton-Ward.
Aezethril (of the episode Endgame) is voiced by Sylvester McCoy. His real name is also Sylvester.
Development Gag: Interestingly, Brains', ah, ah, Speech Impediment from the original series is almost completely gone in this version. This could serve as a nod to Gerry Anderson's proposed Thunderbirds remake, T-Force, in the 1980s, in which the stammer would have been gone entirely, rendering Brains to be actually quite an eloquent speaker (which he is here).
Distanced from Current Events: The episode "Inferno" was held back from airing in the UK in 2017 due to the Grenfell Tower incident (where a tower block of flats caught fire) having occurred months earlier. It still aired in Australia.
Fake American: Usually (exceptions includes Sandra Dickinson as Grandma and Rich Hall as Capt. Taylor).
Name's the Same: With the exception of the exclamation mark, this series has the same title as the 1966 film.
The Other Darrin: Due to the Thunderbirds TV series dating back to 1965 and most of its cast having retired, being too old, or having died long ago, every role was inevitably recast:
Despite David Graham coming back to voice Parker, he's been replaced by Kayvan Novak as Brains and David Menkin as Gordon.
Rosamund Pike voices Lady Penelope instead of Sylvia Anderson.
Due to Christine Finn's death in 2007, Sandra Dickinson voices Grandma Tracy.
Scott and Alan are voiced by Rasmus Hardiker. Their respective original voice actors, Shane Rimmer and Matt Zimmerman, were in their early 80s at the time of the show's airing. Rimmer has since died.
David Menkin also replaced David Holliday and Jeremy Wilkin as the third voice of Virgil.
Ray Barrett, the original voice of John and the Hood, died of a brain hemorrhage in 2009. As a result, in this series, John and the Hood are respectively voiced by Thomas Brodie-Sangster and Andres Williams.
Out of Order: Thanks to being shown on ITV on a bank holiday weekend instead of the usual CITV morning timeslot, episode 13 ("Tunnels of Time") aired tenth.