- Role Reprise: Fred Arminsen (Brainy), Hank Azaria (Gargamel), Gary Basaraba (Hefty), George Lopez (Grouchy), Frank Welker (Azrael), and Anton Yelchin (Clumsy) from the first movie.
- The Other Darrin: Jack Angel and Melissa Sturm do the voices for Papa and Smurfette. Also there were replacement voices for Jokey, Handy, and Chef.
- What Could Have Been: Katy Perry was eager to reprise her role of Smurfette but couldnt because of scheduling conflicts with her tour, so Melissa Sturm replaced her.
Trivia / The Smurfs: A Christmas Carol