- The Other Darrin: Ty Burrell could not reprise Mr. Peabody from the movie because he was busy working on Modern Family. Chris Parnell (Saturday Night Live, Rick and Morty) takes over as Peabody for the series.
- Playing Against Type: While his character is subjected to various Amusing Injuries in this incarnation, the sophisticated and ever-calm Mr. Peabody is still a far cry from Chris Parnell's usual roles of total losers.
- Promoted Fanboy: Jane Lynch grew up watching the original "Peabody and Sherman" cartoons when she lived in Chicago. In the episode with Catherine the Great, Lynch guest stars as Corrupt Corporate Executive Bernadette Steele.
- Role Reprise:
- Screwed by the Network: It was taken off Universal Kids' schedule on July 8, 2019 for unknown reasons.
Trivia / The New Mr. Peabody & Sherman Show