- Acting for Two: For the TV Drama, Sanae Jonouchi portrays Kayo and the Snow Princess, while the White Rabbit/Takamaru and Seikichi are both played by Masaki Kyomoto.
- Hey, It's That Sound!: The Raccoon Mario transformation sound effect from Super Mario Bros. 3 originated in this game.
- Marth Debuted in "Smash Bros.": A minigame based on this appears in Nintendo Land, even though it's never been released outside of Japan. Takamaru and the eponymous castle similarily appeared in Samurai Warriors 3. The game's main theme and a sticker of Takamaru also appeared in Super Smash Bros. Brawl (the Takamaru Assist Trophy in the fourth game is a borderline case, as it was announced before Murasame Castle's US release but Smash itself came after).
- No Export for You: It didn't get a Western release until 2014, nearly 30 years later.
Trivia / The Mysterious Murasame Castle