- The Other Darrin: Lilly Aspell did not voice young Diana for this movie. Instead, she was voiced by Grey DeLisle.
- Role Reprise:
- Phil LaMarr is once again voicing John Stewart, who first voiced him in Justice League.
- Fred Tatasciore returns to voice Jor-El, after he previously voiced him in Teen Titans Go! To the Movies.
- Studio Hop: While averted on the Super Hero Girls side of things, the TTG! animation is also handled by Boulder Media instead of one of that series' usual studios.
Trivia / Teen Titans Go! & DC Super Hero Girls: Mayhem in the Multiverse