- B-Team Sequel: James Whale had no desire to make any more horror films and thus didn't return to direct.
- The Character Died with Him: Colin Clive died before production began, and Baron Henry Frankenstein is all but stated to have died between the events of this film and the previous film, Bride of Frankenstein.
- Uncredited Role: Surprisingly for a film as dependant on make-up effects as this one, make-up supervisor Jack Pierce receives no on-screen credit for his work.
- What Could Have Been:
- Writing by the Seat of Your Pants: Due to the lack of a prepared script, much of the picture was written just moments before the actors were to shoot their scenes. This was how director Rowland V. Lee was able to keep Bela Lugosi working throughout filming, and built up the role of Ygor, which never appeared in the original Wyllis Cooper screenplay.
Trivia / Son of Frankenstein