Believe it or not, Sly Cooper: Thief of virtue was never intended to be a comic; it was originally just the author's idea for a new Sly Cooper game after he was inspired by the last installment, Thieves in Time. Eventually it ended up becoming a comic the author worked on up until 2017.
In page 232, Lady Venom's dialogue originally had something to do with how hungry she was as she was being arrested. The author felt that the way he wrote it made her seem too "self-incriminating", and changed the dialogue around so that it seemed like she was trying to deny what she was doing behind the scenes.
On the medallion that Jack Lupus gave his son Drake, the Chinese symbol "家" is spotted in the middle which translates to "family" in English.
Judge Shelby was created out of the author's disdain of the real life Utah state judge Robert J. Shelby, whom he refers to as an "activist judge".
The author states on page 274 that Torus is meant to be a black character, clearing up any confusion regarding Torus' race.
Artist Disillusionment: The author expressed this at least twice during the making of the comic in 2015 and 2016.
Dear Negative Reader: The author wrote two journal during the production of the comic that subtly calls out viewers; the first one was for those who were critical of his characters (implied to be specifically about Torus) or with political topics in general as to why he wasn't posting any new pages sometime after the halfway point of his comic, and the second (which was deleted shortly after) expressed his dwindling patience with his fanbase after a certain page of "Wrath of the Wolf King".
Fan Nickname: Sly's father is frequently called "Dad Cooper" by the critics of the comic.
I Knew It!: It was speculated that Torus had been responsible for Jack's death and the events of the comic after the last few pages of "Welcome to the Jungle". When the second side story "To Protect and Serve" was released, its confirmed that Torus ratted out Jack Lupus' affiliation with Sly's father, which lead to Clockwerk hunting down Jack in the flashback during "Wrath of the Wolf King".
Name's the Same: Eddard "Ned" Gray is literally named after the Game of Thrones character Eddard "Ned" Stark.
Promoted Fanboy: Averted; although the comic was popular with some of the fandom, it's still regarded as a fanwork.
Reality Subtext: The author does not hold back on any conservative subtext with a few political issues that were prevalent at the time in certain scenes of the main comic and the sidestory "To Protect and Serve" and "The New Director". This includes topics like Judicial activism, Police-related brutality/shootings along with the public's reactions towards them, feminism, and Gun control. Much of the subtext is inserted through the dialogue of the author's characters.
Word of God: The author of the comic has shared a few hidden details about characters within his talks with the viewers.