- Acting in the Dark: None of the cast knew the identity of the killer until the last day of shooting, and none of them got the last ten pages of the script until it was time to film them.
- Actor-Inspired Element: Duane Martin suggested that Joel would go Screw This, I'm Outta Here! after Randy gets killed.
- Awesome, Dear Boy: Sarah Michelle Gellar agreed to star in the film for this reason, despite being busy filming season two of Buffy and I Know What You Did Last Summer at the same time. She even signed on before reading the script.
- Cast the Runner-Up: Rebecca Gayheart had auditioned for the role of Tatum Riley in the first film and auditioned multiple times for Cici Cooper, Hallie, and Maureen Evans before obtaining her eventual role.
- Contest Winner Cameo: The usher who gives masks to Maureen and Phil at the beginning won a contest sponsored by MTV to appear in the movie.
- Enforced Method Acting: As in the first film, Roger Jackson was kept separate from the rest of the cast so they could not put a face to the voice - though he was on set to deliver his lines. As a result they were all very intimidated by him. The exception was Sarah Michelle Gellar, who he says would chat amiably with him on the phone in between takes. She is Buffy, after all.
- Executive Meddling: Wes Craven expected this and he deliberately made some scenes more violent and gory, anticipating that the censors would want them toned down - the toned down versions being the ones he really wanted. Instead the censors agreed to give the film an R rating with the original scenes they were shown, feeling the film's message warranted the violence.
- Harpo Does Something Funny: Several parts of Kevin Williams' script literally just had "Wes Craven will make it scary" for certain sequences.
- Hostility on the Set: It has long been rumored that Wes Craven did not get along with Sarah Michelle Gellar, feeling that she had a tendency to Wag the Director. Allegedly, the character of Sarah Darling in Scream 3 was a Take That! at Gellar.
- Real-Life Relative: Lewis Arquette (Chief Hartley) was the real-life father of David Arquette and father-in-law of Courteney Cox.
- Reality Subtext: Randy alludes to nude photos of Gale appearing on the internet, something that had happened to Courteney Cox just before production began.
- Recycled Set: The bathroom scene in Stab is the same one used in the first film.
- Romance on the Set: Sarah Michelle Gellar and Jerry O'Connell dated during shooting.
- Troubled Production: The film ran into issues after one of the extras leaked its script to the internet (one of the first major film leaks in the digital age). As a result, the film's script was almost entirely rewritten, with pages often being completed the day they were to be filmed. Security was tightened, with everyone required to sign non-disclosure agreements, and the film underwent many reshoots.
- Unintentional Period Piece: The killer's Motive Rant satirizes the era's Moral Guardians and the controversy over violence in the media, which was already brewing at the time even before the Columbine massacre, and name-drops Bob Dole, the Christian Coalition, and various members of O.J. Simpson's legal team, such that even the other killer, Mrs. Loomis, explicitly refers to this motive as a product of the '90s.
- What Could Have Been:
- The film originally ended with a shot with another Ghostface◊ watching over from the campus' bell tower. There is fan speculation that it is Roman Bridger under the mask.
- Sarah Michelle Gellar's role was completely different. She was originally meant to appear in the scene with the sorority sisters inviting Sidney to the party. The scene which she does appear in - the film class discussion - had a different student giving her lines.
- According to a rumor, the identity of Ghostface was changed after the original script was leaked on the internet - it was Derek and Hallie in the original ending. This was referenced in the next film where all the actors on Stab 3 were kept in the dark about the script for this reason (this also prompted increased security on shooting and convinced the crew to destroy any script material after filming).
- Other original character details included: Randy being Gale's new cameraman, Joel being a med student and friends with Sidney, Derek being a film student always going around with a camera (like Robbie in the fourth film) and Debbie Salt being incredibly rude and bitchy - asking Sidney if she was the one murdering everyone, and getting punched in the face by Gale.
- Mickey was the one who would have sang in the cafeteria. He would have sung to Hallie, rather than Sidney. And the song would have been Whitney Houston's "I Will Always Love You". He also would have taken a bullet for Sidney in the final encounter with Derek and Hallie; Mickey was not one of the characters considered for one of the killers in the original draft (Mrs. Loomis was on the radar, and the other three characters who played antagonistic roles in the early script were also in consideration).
- The ending would have been darker with Cotton deciding to shoot both Gale and Sidney, claiming they'd ruined his life (this would have led to there being THREE killers; the two in the Ghostface costumes, Derek and Hallie, and then Cotton, who never donned the costume but was the Final Boss). Sidney would have stabbed Cotton and the two would have laid dying next to each other. Presumably this would have ended the franchise with this movie.
- Alicia Silverstone and Reese Witherspoon were considered for Cici Cooper.
- Denise Richards was offered a role in the film, but she was busy doing Starship Troopers.
- Working Title: Various titles were considered for the sequel at different points in the film's production, including Scream Again, Scream Louder, and Scream: The Sequel.
- You Look Familiar: Matthew Lillard (Stu Macher in the first movie) has an uncredited cameo here.
Trivia / Scream 2