- Acting for Two:
- In episode two, Kate Micucci voices Velma and April from The Funky Phantom. Additionally, Tom Kenny voices Augie and Mudsy in the same episode.
- In episode three, Frank Welker voices Magilla Gorilla, albeit only in more realistic ape grunts this time around in addition to his usual roles of Scooby and Fred.
- "A Haunt of a Thousand Voices!" has the gang meeting their voice actors.
- Adored by the Network: The series was renewed for a second season before it even premiered. It no doubt was caught up in the AT&T planned reorganizing of Warner Media. It was started before the merger was complete, but it was kept in production with the season two pick up when the other HB/RS/MGM legacy properties were quietly ended, most of which with episodes not yet on Boomerang. While full reorganization of the channel under AT&T has yet to be realized (as AT&T has pretty much decided to end separate Turner management by giving Cartoon Network and Boomerang to Warner Bros in their entirety), the decision to have this series air on Cartoon Network first before ending the other legacy series on Boomerang implies heavily Guess Who? was already prepared to be the new starting point. However, since then it seems this show will wrap production after Season 2 (or 4, if they are split in halves). AT&T being very mum about their overall plan for Cartoon Network has lead to the belief if they do want a refresh of the HB brands as a whole, it isn't here yet. Also note this show and Jellystone were in the works before the court ruling came down, while the new Flintstones was not.
- Channel Hop: The series was always meant to air on Boomerang, but repeats aired on Cartoon Network. However, Cartoon Network dumped the show after six episodes, and it became a Boomerang exclusive. Then, for Season 2, it got heavily promoted as being part of HBO Max, where it aired its final episodes.
- Fake Brit:
- Ian James Corlett, who is Canadian-American, plays Sherlock Holmes.
- New York-born Steven Weber reprises his role from Batman: Return of the Caped Crusaders and Batman vs. Two-Face as Alfred.
- Invisible Advertising: While Warner Brothers releases myriad promos for new episodes online, on Cartoon Network proper there are no advertisements for new episodes of this series, which run once a week (initially twice a week before its encore slot was paved over with Ben 10 (2016) and Teen Titans Go!), except for a one second blurb while the episode is already running that the show is "next". This is in stark contrast to one of the other three WB animation shows currently running on CN, Teen Titans Go!, which often has a countdown timer obscuring part of the new Scooby Doo episode to promote -its- new episode screening later in the day which is promoted every commercial break and then rerun often.
- Meaningful Release Date:
- "What A Night For A Dark Knight", the episode where Batman guest-starred, was released two days before Batman's anniversary day, September 21, 2019.
- Alex Trebek’s episode, "Total Jeopardy!", was aired five days after his death as a tribute.
- Milestone Celebration: The show came out in 2019, the 50th anniversary of the Scooby-Doo franchise.
- Out of Order: While still episodic, there are instances of episodes airing out of order. For example, Chris Bailey said how the 13th episode that aired, which is the Batman episode, is the pilot .
- In "The High School Wolfman's Musical Lament!" from season 1, two clips of the gang's past mysteries are actually from season 2 episodes "The Horrible Haunted Hospital of Dr. Phineas Phrag!" and "A Fashion Nightmare!".
- Posthumous Credit: Alex Trebek passed away just five days before his episode, "Total Jeopardy!", was released.
- Promoted Fanboy: Jaleel White made it clear on Twitter that acting in a Scooby-Doo show is a bucket list item for him, as a signed Scooby-Doo animation cel is one of his prized collectibles.
- Rereleased for Free: The whole series is free to watch on Tubi starting on June 2023.
- Role Reprise:
- Tom Kenny reprises the role of Mudsy aka The Funky Phantom from his appearance on Scooby-Doo! Mystery Incorporated.
- Kevin Conroy reprises the role of Batman, having portrayed the character in multiple animated series, animated movies, and video games ever since Batman: The Animated Series.
- Also, it was inevitable, but Mark Hamill returns as the Joker, as well as the Trickster and As Himself!!
- The voice of Alfred from the DCAU is sadly no longer with us, so instead, he is voiced by Steven Weber, who previously played the role in Batman: Return of the Caped Crusaders and Batman vs. Two-Face.
- Jaleel White reprises his role as Steve Urkel from Family Matters.
- Rachel Kimsey voices Wonder Woman, much like how she did on Justice League Action.
- In addition to Fred and Scooby as always, Frank Welker also reprises the role of Speed Buggy, who he previously voiced in "Bravo Dooby Doo" and Scooby-Doo! Mystery Incorporated, as well as his role of Dynomutt.
- Charlie Schlatter reprises the role of The Flash, though in a first, it's explicitly clear which Flash he's voicing: Barry Allennote
- As per usual, Jennifer Hale, Kimberly Brooks and Jane Wiedlen reprise the roles of the Hex Girls.
- In the French dub, in addition to the current voice actors for the Scooby gang, Blue Falcon is voiced by Paul Borne, reprising his role from Scooby-Doo! Mystery Incorporated. Also, several voice actors from previous DC Comics adaptations reprise their roles here:
- From The Batman: Adrien Antoine as Batman and Christophe Lemoine as the Flash.
- From Superman/Batman: Apocalypse: In addition to Batman, Delphine Braillon as Wonder Woman.
- From Batman: The Brave and the Bold: In addition to Batman, Wonder Woman, and Flash, Xavier Fagnon as the Joker.
- Screwed by the Network: In addition to receiving next-to-no reruns and the aformentioned Invisible Advertising, Cartoon Network just stopped airing the show after 6 episodes despite initial reports saying that episodes would air there a week after Boomerang and clips on days the episodes would have aired being uploaded. Fortunately, the show would eventually be added to Boomerang a little over a year later, with heavy advertising and much better timeslots. The series did return to Cartoon Network's lineup in October 2022 for Scoobtober however, and has been airing even after Scoobtober ended.
- What Could Have Been:
- One of the promotional posters depicts Batman in his Justice League Action design.
- Courage the Cowardly Dog was going to make an appearance in the show. The idea was eventually repurposed into Straight Outta Nowhere: Scooby-Doo! meets Courage the Cowardly Dog.
- The gargoyle shown in the Gigi Hadid episode originally had hind quadruped legs before he was eventually redesigned to have more humanoid legs.
- Alton Brown's episode was meant to be in season 1, but it was eventually put in season 2.
- The title card for the Tim Gunn episode showed that he was going to hold the gang's outfits, but it would've made the title card too hard to read. The final title card has him in a pose instead.
- There is concept art for Mel Brooks, Dolly Parton and KISS that went unused.
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