What Could Have Been: Around the early 90's or so, Steve Purcell received an offer from Marvel to produce Sam & Max comic strips for them. He declined, opting instead for LucasArts and Hit The Road. Who knows what might have happened if he had taken them up on their offer? In an odd twist of fate, Purcell now works for a subsidiary of the company that owns both Marvel and LucasArts.
The Other Darrin: Andrew Chaikin plays Max in Episode 101, but (apparently due to health reasons) was replaced by William Kasten. As of Season 3, Chaikin is back, but instead of playing Max, he plays The Narrator. Which is kind of playing Max anyway — the Narrator is actually Max's long-dormant superego. As of Poker Night 2, Max's voice actor changed once more to Dave Boat.