- Dear Negative Reader: In an interview, Joseph Gilgun preemptively says as much to potential detractors of the series who do so out of belief that their religion had been mocked, saying "Fuck 'em" when asked about the show receiving such backlash.
- Deleted Role: It was originally intended that the non-supernatural villain of the first season would not be Odin Quincannon, but a Gender Flipped version of him called Vyla Quincannon, played by Elizabeth Perkins. The decision to go with Odin instead was made late enough that a few sequences with Vyla were actually filmed for the pilot episode, and included as deleted scenes on the DVD release.
- Development Hell: Garth Ennis had been trying to get Preacher to be adapted to film for a while, even writing multiple screenplay drafts. However, the very controversial themes of the series, such as the anti-God tone (to the point of having God Himself as the main villain), discouraged investors from financing the project. When plans for a film fell through, the series was about to have a home on HBO. But newly hired executives abandoned the idea out of concern over the anti-religious themes of the story. Before AMC officially picked up the series, Columbia Pictures had bought the rights to produce a Preacher movie with Sam Mendes attached to direct.
- Fake American:
- Dominic Cooper and Lucy Griffiths are British.
- Ruth Negga is Irish-Ethiopian, born in Ethiopia to Irish and Ethiopian parents, then raised in Ireland.
- Graham McTavish is Scottish.
- Fake Irish: Joseph Gilgun is British.
- Fake Nationality:
- British Pip Torrens as Herr Starr and Anglo-Australian Noah Taylor as Hitler, both German/Austrian (of course).
- Since season 4 is filmed in Australia, the majority of the minor characters are played by Australians pretending to be various other nationalities.
- In Memoriam: The season two premiere was dedicated to Steve Dillon, who passed away in October 2016.
- Playing Against Type: This isn't really something one would expect Seth Rogen to produce or even direct, though he has been involved in dark, satirical and apocalyptic works before.
- Real-Life Relative: Ruth Negga and Dominic Cooper were a romantic couple for several years. Downplayed in that they later revealed they'd broken up around 2016 (the same year Preacher premiered), but kept it private until halfway through the show's run, and still describe themselves as best friends.
- Role Reprise: Noah Taylor previously played Adolf Hitler in the 2002 film Max.
- Those Two Actors: This isn't the first time Dominic Cooper and Ruth Negga played a romantic couple.
- The Wiki Rule: Here.
- What Might Have Been: Throughout the Development Hell with films and HBO, Samuel L. Jackson had been attached to play the Saint of Killers.
- Word of Gay: The creative team have confirmed that DeBlanc and Fiore were a couple. An interesting example since it's all but stated in canon, but since they're angels, it still needed clarifying that human concepts like romance and sex were indeed something they'd be interested in and capable of.
Trivia / Preacher (2016)