- Unintentional Period Piece: The comic is very much a snapshot of the 1990s.
- Jesse is constantly railing against "politically correct" language and culture, which was a buzzword of the 1990s. However, this could also count as Values Resonance given political correctness's resurgence in The New '10s.
- Arseface tried to kill himself over Kurt Cobain's suicide.
- The Twin Towers feature prominently in Cassidy's ode to New York City.
- Jesse chews out a Frenchman for testing out atomic bombs. France's last atomic test was in 1996.
- The turn of the millennium is a plot point, and Cassidy states that he's "as old as the century."
- On a meta note, in the letters sections of each issue, Garth Ennis offered his original scripts to fans who wrote in a letter identifying a quote or reference. Sometimes a quote would go unidentified for a whole issue. If readers had access to the Internet, they could simply look up the answer.
- Jesse's story to Cassidy of seeing a Bill Hicks show a "couple of months" before Hicks's death means that Jesse stumbled into one of Hicks's last shows, which could've been no later than December of 1993; Hicks stopped touring in early 1994.
Trivia / Preacher