- Approval of God: While Craig McCracken was not involved with the show beyond the conception stage and admits to having never watched it himself, he did sort of gave it his blessing.
- April Fools' Day: The announcement of a Magical Girl anime series Inspired by the American The Powerpuff Girls was assumed to be an April Fool's joke, since it was announced on April 1st, 2005. Doubly so since after the announcement was made, there was absolutely no new information, other than denial it was an April Fools Joke, about it until April 1st, 2006.
- The Danza: David Hurwitz voices Buttercup's older brother Dave.
- No Export for You: The series has never been broadcast in the United States. Reportedly, this was because a dub separate from the one by The Ocean Group was planned, but never materialized.
- As far as Europe is concerned, the anime only aired in the Mediterranean countries.
- Only So Many Canadian Actors: As far as the English-language dub is concerned, this is currently the only incident of this happening in the entirety of the The Powerpuff Girls franchise. Only time will tell if Vancouver will portray Townsville again in the upcoming live-action Powerpuff show.
- The Other Darrin:
- Most of the voice actors from the Japanese-language dub of the original cartoon were recast for this series. For example, Emiri Katou replaces Kaori Asoh as Blossom.
- As of 2021, the dub is the only Powerpuff thing without any connection with the original show.
- Matt Hill voiced Poochi for the first 37½ episodes, then his nephew Simon took over the rest of the series.
- Playing Against Type:
- Hikaru Midorikawa, known mostly for cool-headed Bishōnen characters, plays the part of the Piano Forte, a very irritable Piano monster.
- Junichi Suwabe, known for playing suave Bishōnen characters, plays the part of the laughably Camp Gay Great Michel.
- The English dub of the TV series had a very surprising example of this trope with Richard Ian Cox as Big Billy (later known as Big Boy). Out of all the Gangreen Gang members Richard Ian Cox played Big Boy, granted he does try to do a different type of voice though. (But of course this could belong to WTH, Casting Agency?.)
- Real-Life Relative: Both Poochi's English voice actors are uncle (Matt Hill) and nephew (Simon Hill).
- Relationship Voice Actor: Since the actors who did the English dub are all associated with The Ocean Group, many of them have worked together before.
- This isn't the first time Maryke Hendrikse and Nicole Bouma played Tomboy and Girly Girl characters. Lunamaria Hawke (voiced by Hendrikse) and her sister Meyrin (voiced by Bouma) in Mobile Suit Gundam SEED Destiny had a similar relationship.
- To count, this is like one big Gundam reunion as voice actors that franchise are present here. Matt Hill who happens to be Kira Yamato, Samuel Vincent who happens to be Athrun Zala, Trevor Devall who happens to be Mu LaFlagga, Nicole Bouma who happens to be Meyrin Hawke, Tabitha St. Germain who happens to be Flay Alster, Chantal Strand who happens to be Lacus Clyne, Maryke Hendrikse, Nicole Oliver who happens to be Regene Regetta, Michael Dobson who happens to be Sergei Smirnov and a lot more voice actors to boot in the English Dub.
- Quite a few of the voice actors of the dub also provide voices for My Little Pony: Friendship Is Magic. It's oddly appropriate since that show's creator, Lauren Faust is the wife of Craig McCracken, the man who made the original show. Specific examples are Tabitha St. Germain, Cathy Weseluck, Kathleen Barr and Maryke Hendrikse.
- Role Reprise: The Latin American Spanish dub keeps a good chunk of the cast of the original series, with a few exceptions.
- Science Marches On: This is a 2006 series. Why is the major, obviously on the breaking edge of chemistry, scientist still using FLOPPY DISKS? This is actually a reflection of how Japanese scientists and businesses manage their tech. While Americans view floppy disks and fax machines as obsolete, the Japanese still use them regularly.
- What Could Have Been:
- The original pitch pilot was apparently closer in tone and characterization to the source cartoon, showcasing much more action and destruction.
- Concept art shows a variety of unused designs◊, some of which are simply more animesque versions of their original Western appearances. There's even a better look at the pitch pilot designs◊. It's unknown if the girls were still related in any of these earlier concepts, or if the change had already been made at that point.
- Apparently, some of the voice cast of the original 1998 show expressed interest in making their own dub of this.
- The Wiki Rule: The Powerpuff Girls Z Wiki.
Trivia / Powerpuff Girls Z