- California Doubling: The show is set in Austin, but filmed in Los Angeles.
- The Danza: Billy Tyson is played by Billy Burke
- Produced By Castmember: Rob Lowe is a co-executive producer.
- Queer Character, Queer Actor:
- Real-Life Relative: Jon Foster, who plays Dustin, the ex of Michelle's (played by Liv Tyler) missing sister, is Liv's real life brother-in-law.
- Real Life Writes the Plot: The COVID-19 global outbreak appears in-universe.
- Liv's character had to be Put on a Bus due to the pandemic happening and she was in London at the time filming started.
- Masks are worn throughout the series.
- Covid effects characters within the series, characters' jobs and businesses turn bad, a character's cancer gets effected by him contracting the virus, characters are seen quarantining, social distancing, and having Zoom calls.
- Ripped from the Headlines: The fertilizer plant explosion in the pilot episode is clearly based on the West Fertilizer Company explosion of April 2013, which resulted in the deaths of ten firefighters.
- You Look Familiar: Two cast members previously appeared on 9-1-1:
- The Wiki Rule: The 9-1-1 Wiki covers both the original 9-1-1 and Lone Star.
Trivia / 9-1-1: Lone Star