- B-Team Sequel: Paul W.S. Anderson had nothing to do with this film, as he'd moved on to Event Horizon.
- Creator Backlash:
- Mortal Kombat creators Ed Boon and John Tobias were not fond of this movie, and denounced it as the worst part of the franchise.
- Marjean Holden (Sheeva) was not pleased with how her character was killed off in this movie and and said as such in a 2001 interview.
- While Christopher Lambert speaks highly of his role in the first film, he admitted to passing on the sequel because he didn't like the script.
- Creator Killer:
- Director John Leonetti's budding directorial career was appropriately annihilated by Mortal Kombat: Annihilation; almost all of his work for the next 16 years (outside of The Butterfly Effect 2) was back in his usual job as cinematographer, before he made a second, somewhat more successful transition to director in the mid-2010s.
- For producer Lawrence Kasanoff, which was a double flawless with the protracted production of his animated film Foodfight!; that movie's failure killed his cinematic career.
- Dawson Casting: Inverted; while Sindel is supposed to be Kitana's mother, Musetta Vander is only four years older than Talisa Soto, and looks to be about the same age as her onscreen. However, Edenians are all youthful-looking immortals in the games, so it's a bit justified.
- Dueling Movies: With another dark fantasy film from New Line, Spawn.
- Fan Nickname: Get into any discussion of Mileena online and see how long it takes someone to refer to her as "You Wish".
- Franchise Killer: There were plans for a third movie, but disappointing box office returns saw them sent on a one-way trip to the Netherrealm. Years later, there were serious talks of a new movie, that may or may not have been a true sequel, but production difficulties led to it being scrapped. It wouldn't be until 2019 that a reboot would be announced with James Wan as producer.
- The Other Darrin:
- Done with several of the main characters. The only actors from the first film to return for the second were Robin Shou (Liu Kang) and Talisa Soto (Kitana).
- Christopher Lambert decided against reprising his role as Raiden to appear in Beowulf instead.
- Linden Ashby was asked to reprise his role as Johnny Cage, but declined because he was unceremoniously killed off five minutes into the movie.
- Aside from the main cast, only one actor from the first film returned for the sequel, namely, stunt double Keith Cooke. Here, however, he plays Kuai Liang, the younger of the Sub-Zero brothers; in the first film, he was Reptile's humanoid ninja form.
- What Could Have Been:
- Just like in the first movie, Michael Jai White was slated to portray Jax. Ultimately, he turned down the role, this time to do Spawn. He finally portrayed Jax in Mortal Kombat: Rebirth and Mortal Kombat: Legacy.
- In an early script for the movie, Smoke was supposed to aid Mileena in the attempt to assassinate Sonya.
- Stryker and Kabal's brief mention was supposed to lead into a subplot where they were captured together with Kitana and they would have joined the fight in the climax. They were cut out presumably because the movie was cluttered as it was.
- The shooting script had a fight between Sheeva and the mortal Raiden. This fight was used in the novelization, however.
- There was supposed to be a Sequel Hook with Quan Chi making an appearance.
Trivia / Mortal Kombat: Annihilation