- Actor Allusion: The Latin American Spanish dub features some voice actors with some story on dubbing boxing-related works:
- Domoto, a shady promoter, is voiced by Pedro D'Aguillon Jr., who voiced Don King, a very Real Life shady promoter, in the Latin American Spanish dub of the Don King: Only In America TV film about his life. He also voiced Michael Buffer in Creed and Ramuda Ruslan in Hajime no Ippo.
- Unsurprisingly enough, many of the voice actors also worked in many of the dubs from the Rocky franchise:
- Humberto Vélez, who voice Nanbu, pulls this twice: He voiced Paulie in Rocky Balboa, and the second episode, he sings the opening theme of The Simpsons, when he voiced Homer Simpson up until the 15th season.
- Yabunuma is voiced by Arturo Mercado Sr., who also voiced Paulie from the very first film to the fifth, not to mention Rocky himself in the first dubbed version of Rocky II. Interestingly enough, his real life son, Arturo Mercado Jr., voice Aragaki, his star boxer.
- Enrique Cervantes (Burroughs) voiced Tony Evers in Creed and Little Duke in the sequel.
- Curiously enough, both the original Japanese and Latin American Spanish dubs has some voice actors who worked in the dub of Undisputed, another film about boxing:
- From the Japanese side, Hisao Egawa (Potemkin Higuchi) voiced George "Iceman" Chambers, the antagonist of the film. Also, Yohei Tadano (Miyagi) voiced Ratbag.
- On the Latin American side, Humberto Solorzano (Fujimaki) voiced Monroe Hutchens, the protagonist.
- The Cast Showoff: In the Latin American Spanish dub, all the rap insert songs are sung by Leslie Gil, Sachio's voice actress, along with Leyla Rangel, which doesn't voice anyone in the series.
- Milestone Celebration: The series was made as a celebration for Ashita no Joe's 50th anniversary.
- Name's the Same: The champion of Megalo Box, who is implied to be russian, should not be compared with neither Yuri or Yurio from Yuri!!! on Ice.
- Real-Life Relative: Yabunuma and Aragaki's voice actors are father and son in Real Life in the Latin American Spanish dub (see above).
- Relationship Voice Actor:
Trivia / Megalo Box