- Descended Creator: Co-writer and co-voice director Rachel Ramras voices Lola.
- Directed by Cast Member: In addition to playing Lola, Rachel Ramras co-directed the voice actors.
- Written by Cast Member: Ramras also co-wrote the script and co-wrote the song "Girl, You're Fabulous".
- The Other Darrin: Some recasting of characters from The Looney Tunes Show is done here...
- Co-writer Rachel Ramras voices Lola Bunny, doing an imitation of Kristen Wiig, whom voiced Lola on The Looney Tunes Show.
- Pete Puma is voiced by Jess Harnell, having previously been voiced by John Kassir.
- Damon Jones voices Marvin the Martian, whom provided Marvin's rapping voice in The Looney Tunes Show but not the speaking voice (done by Eric Bauza).
- Role Reprisal: In the main voice cast, Rachel Ramras (Lola) and Jess Harnell (Pete Puma) are the only actors who haven't played their characters before.
- Talking to Himself: Jeff Bergman, whenever Bugs Bunny and Daffy Duck interact.
- Those Two Actors: Rachel Ramras and Jim Rash (Lola and Cecil) worked together in Mike Tyson Mysteries.
Trivia / Looney Tunes: Rabbits Run