- Actor-Shared Background: James mentions living in Englewood. John Travolta was born in Englewood, New Jersey.
- California Doubling: The story takes place in New York, but the movie was mostly filmed in Vancouver, Canada.
- Career Resurrection: Kinda, sorta, for John Travolta. While Pulp Fiction would provide the full-blown resurrection, it's safe to say that these movies at least got him back in the public eye long enough until then.
- Channel Hop: Amy Heckerling first pitched the movie to Disney. Michael Eisner felt that it was too sexual for them even for their Touchstone Pictures banner. Paramount Pictures, Warner Bros., Orion Pictures, 20th Century Fox and Universal Studios also passed on it too. Ultimately it was TriStar Pictures who liked the script and green lit the film with a $7 million budget.
- Harpo Does Something Funny: All of Mikey's dialogue was Bruce Willis ad-libbing over the finished footage.
- Inspiration for the Work: Amy Heckerling was inspired to write the film after her husband and writer Neal Israel started playfully talking in a different voice to pretend what their new baby would say. Her husband also has a cameo as Mollie's boss.
- Name's the Same: This is one of two films, released only a year apart, to have a heroine named Mollie Jensen. Though the other one is perhaps better known.
- The Other Darrin: Joan Rivers was asked to reprise her cameo as Julie to a full appearance in Look Who's Talking Too, but she had to drop out.
- Real-Life Relative: Amy Heckerling's father Louis Heckerling plays Mollie's father. Like his character in the film, he was also an accountant.
- Recycled: The Series: A short-run TV series of LWT aired between 1991-1992 under the title 'Baby Talk starring Scott Biao and Tony Danza as the voice of Mickey. George Clooney also had a small role on the series and has mentioned it was the quickest exit he ever took filming anything.
- Romance on the Set: According to Kirstie Alley in her memoir, she fell in love with John Travolta during filming, but she stayed faithful to her husband.
- What Could Have Been:
- The original film was set to have much filthier, R-rated dialogue, especially for Mikey which Bruce Willis recorded a bit of. They eventually decided to clean it up a bit due to some poor test reactions.
- Dan Aykroyd, John Candy, Chevy Chase, Steve Martin and Bill Murray were considered for the voice of Mikey, but all of them were busy. Chase was busy doing National Lampoon's Christmas Vacation, Murray and Aykroyd were doing Ghostbusters II, Martin was busy shooting Parenthood and Candy was doing Uncle Buck.
- John Stamos was asked to play James, but the producers of Full House wouldn't allow him to appear due to contractual reasons. Jeff Goldblum, Mel Gibson and Michael Keaton were also considered.
- Geena Davis was asked to play Mollie, but she declined as she didn't want to do a movie involving a birth sequence, especially with her birth sequence in The Fly (1986).
- Richard Pryor was going to voice Eddie in Too, and even recorded lines, some of which can be heard in the first trailer. He was replaced with Damon Wayans due to having to drop out from illness.
- The role of Mollie's accountant date Harry was originally intended as a cameo role for Amy Heckerling's friend/fellow director John Landis. But he declined as he didn't really like working on movies involving with kids, especially after what happened with him during the making of Twilight Zone: The Movie.
- Working Title: Big Talk, Daddy's Home and Daddy Wanted.
Trivia / Look Who's Talking