- Actor-Shared Background: Jason Statham used to be a street vendor.
- Amateur Cast: Of the 44 speaking parts in the film, 17 were played by people who had never acted before.
- Breakthrough Hit: For Guy Ritchie and Matthew Vaughn.
- Cast the Expert: Before becoming an actor, Jason Statham was training to be an Olympic diver (for which, presumably, he shaved). To make money while he trained, he became a street seller (not entirely legal). Guy Ritchie needed a street-wise seller—lo and behold, in comes Statham. Strangely, he has yet to demonstrate his diving abilities.
- Completely Different Title: In Russia, the film was translated as Karty, den'gi, dva stvola (Cards, Money, Two [Gun]barrels).
- The Danza: Alan Ford plays a character named Alan.
- Deleted Role: Supermodel Claudia Schiffer was originally cast as Eddie's girlfriend. She completed filming but was later edited out after negative test screenings.
- Follow the Leader: Just about every British gangster film in the late nineties and early 2000s tried to emulate this film.
- In Memoriam: The movie was dedicated to Lenny McLean, who played Barry the Baptist. He died of cancer exactly one month before the movie's debut in England.
- Irony as She Is Cast: Eddie is supposed to be a card sharp. According to Dexter Fletcher, Nick Moran is a terrible poker player in real life.
- Orphaned Reference: Stephen Marcus (Nick the Greek) was originally cast as Tom, hence why the character is constantly referred to as fat.
- Recycled: The Series: The film had a surprisingly good but short-lived spin-off series of hour-long episodes.
- Sleeper Hit: A low budget film from a first-time director and cast consisting mostly of unknowns (of the 44 speaking parts in the film, 17 were played by people who had never acted before). In fact, according to Matthew Vaughn, it almost went Direct-to-Video in America, until producer Trudie Styler called her friend Tom Cruise, who attended a screening, loved it and convinced the studio to give it a proper release.
- Star-Making Role: Jason Statham, Jason Flemyng and Vinnie Jones.
- Stunt Casting:
- Sting as the bartender father of Eddie.
- Vinnie Jones (an ex-footballer with a reputation as a hard nut) as Big Chris. At the time it was stunt casting, but it led him to a Hollywood career playing very similar characters.
- Lenny McLean as Hatchet Harry's enforcer Barry the Baptist. McLean was better known for his former career as a fearsome bare-knuckle fighter known as the Guv'nor.
- Throw It In!:
- Nick dropping his glass through Rory's table wasn't planned.
- Ed forgetting the guns wasn't scripted. Someone actually forgot to bring the gun props to the set.
- According to Vas Blackwood, Rory's "shistos, pesevengi, gamouri" line wasn't in the script. He drew on having Greek friends. There were two versions written and both were filmed.
- Unintentional Period Piece
- Soap says that things are starting to feel like "a bad day in Bosnia," referencing the then-current Balkan Wars.
- At the very end, Ed, Bacon and Soap scramble to call Tom on their cellphones and all ask each other, "What's his number?!?" Modern cellphones have phonebooks.
- What Could Have Been: Ray Winstone turned down the role of Hatchet Harry.
Trivia / Lock, Stock & Two Smoking Barrels