- Exiled from Continuity: With the exception of Kang the Conqueror, no characters from Fantastic Four or X-Men show up in the game. What makes this particularly jarring is the fact that many of those characters played significant roles in the previous game. Then Disney offered to buy out most of Fox's entertainment assets, including the aforementioned franchises, a month after the game released. Despite the deal eventually being finalized less than two years after the game's released, no DLC featuring said characters was released.
- The Other Darrin: Enforced Trope. Almost all of the cast of the game are played by different actors, due to the then-ongoing voice actors strike. Stan Lee was the only person to return, since while he has done voice work in several video games, he was not a union actor.
- Writer Revolt: Fantastic Four and X-Men characters failed to show up for what were very likely corporate reasons pertaining to Fox owning the movie rights to the characters at the time of the game's development and release. While the game doesn't get particularly aggressive about showing contempt toward the decision to omit X-Men and Fantastic Four characters just because Disney didn't own their movie rights at the time, there's still an obvious attempt to at least offhandedly bring up the characters who showed up last game while not directly referring to them, and takes the time to lightheartedly mock how baffling the whole ordeal is with an Asgardian cooking show being unable to show merchandise due to it being owned by another company.
Trivia / LEGO Marvel Super Heroes 2