- The Other Darrin:
- Jerry O'Connell replaces Alan Tudyk as Superman.
- Rosario Dawson replaces Michelle Monaghan as Wonder Woman.
- Nathan Fillion replaces Justin Kirk as Green Lantern. This also counts as a role reprisal.
- Sam Witwer replaces Steve Blum as Ocean Master, though Blum does reprise his role as Cyborg's computer and another role from another DC movie.
- In the French dub, Jean-François Vlérick is replaced by Boris Rehlinger as Orm and Marc Perez as Cyborg's armor, while Vlérick himself replaces Paolo Domingo as Steve Trevor and Carole Gian replaces Céline Melloul (who here voices Mera) as Sarah Charles.
- The Other Marty: Sean Patrick Thomas had replaced Shemar Moore as Cyborg due to other commitments the latter had, but Moore later became available again, so they decided to redub to provide Cyborg better continuity.
- Playing Against Type: Harry Lennix doesn't play bad guys, with the case of Black Manta.
- Relationship Voice Actor:
- Role Reprise: As with Justice League: Doom and Justice League: The Flashpoint Paradox, Nathan Fillion reprises his Green Lantern: Emerald Knights role as Hal Jordan. Steve Blum also reprises his role from The Flashpoint Paradox as Lex Luthor.
- In the French dub, in addition to having the same role reprisals as the ones from War, there is also Véronique Augereau as Lois Lanenote and Thierry Murzeau as Sam Lane, reprising his role from Justice League: The Flashpoint Paradox.
Trivia / Justice League: Throne of Atlantis