- You Look Familiar:
- Kira Pontiff, who played a number of roles in earlier Mihmiverse movies, appears as Faith.
- Alice Mihm, who previously played Evelyn Johnson in two movies, plays Hope.
- Douglas Sidney plays The Reverend.
- Mark Haider has a cameo as one of the Death Dealers.
- James Norgard appears as The Governor.
- Michael Kaiser has a cameo as the mutant man trying to protect the injured mutant woman.
- Catherine Hansen has a cameo as the injured mutant woman.
Trivia / Guns of the Apocalypse