- Doing It for the Art: The film's studio backers were initially concerned that the terminally ill Spencer Tracy would be unable to make it through the shooting. Kramer and Hepburn put up some of their salaries to back up Tracy's insurance coverage.
- Reality Subtext: Spencer Tracy's final speech wasn't about Matt and Christina; it was about Tracy's own decades-long love affair with co-star Katharine Hepburn. The tears in Christina's eyes during that scene were in fact Katharine's own at Tracy's declaration of love for her.
- Real-Life Relative: Katharine Houghton, who plays Joey, was Katharine Hepburn's real-life niece.
- Those Two Actors: This was the ninth and final screen pairing of Spencer Tracy and Katharine Hepburn.
Trivia / Guess Who's Coming to Dinner