- Actor Allusion: This is the second film in which Tiffany Haddish has appeared with a Scary Movie actress; Regina Hall. She previously appeared in Keanu with Anna Faris, who made a cameo appearance in the film as herself.
- The words "Thug Life" are written on the wall of a crude, run-down motel upon the girls' arrival. "Thug Life" was popularised by Tupac Shakur, who Jada Pinkett-Smith was good friends with since childhood.
- Just before the Flossy Posse step onto the dance floor, Dina says "let's set it off", a reference to the film which starred both Jada Pinkett-Smith and Queen Latifah. The two even give a knowing look to each other after the reference.
- Another Set It Off reference: After Ryan's disastrous meeting with Bethany after drinking the absinthe-spiked drinks, the ladies don colorful wigs and enter the local bar. The wigs are the same color and style Latifah, Pinkett-Smith, Vivica A. Fox and Kimberly Elise wore during one of the robberies in the film.
- Casting Gag: Both Jada Pinkett-Smith and Queen Latifah appeared in the film Set It Off as two of the four friends who serves as the protagonists for that film.
- Playing Gertrude: Tiffany Haddish is actually around 9-10 years younger than each of her fellow cast members as the characters are supposed to be in their early-to-mid forties since she was actually in her late thirties when playing Dina, while Regina Hall, Queen Latifah and Jada Pinkett-Smith were in the same age range as their characters.
- Star-Making Role: For Tiffany Haddish, who after the success of this movie went on to host Saturday Night Live, get a deal with HBO, appear at the Oscars, host the MTV Movie Awards, not to mention the string of new roles and guest appearances just one year after.
Trivia / Girls Trip