- Actor Allusion: Peter has never taken drugs before (or so he claims).
- And the way he looks when he and Ethan finally arrive at the hospital brings to mind Robert Downey Jr. as Sherlock Holmes.
- Zach Galifianakis plays a Manchild Lethally Stupid Fat Idiot who actually started the whole mess. Sounds like Alan.
- Follow the Leader: The film was frequently criticized as being just a rehash of the 1987 film Planes, Trains and Automobiles.
