- Marth Debuted in "Smash Bros.": As this is the first Digimon game to be localized since 2008, this is Mirei and Rina's first official appearance in the West, rather than their game of origin. When factoring in DLC, Sayo would also be making her debut in Europe since the DS games never got released over there.
- No Dub for You: The English-language version uses the Japanese voices. This is widely believed to be Bandai Namco not attributing a budget for one, due to uncertainty over how well the game would sell. A trailer exists with Kyoko doing narration in English, although it specifically makes sure to note that it doesn't apply to the actual game (as it was made after the announcement of the lack of a dub).
- No Export for You: The PS4 version was solely made for international audiences and wasn't available for Japanese players until 2017 as it was released together with its sequel, Hacker's Memory.
- Regional Bonus: The international versions added a hard mode and a New Game+, which were eventually patched into the Japanese version as well. The US and EU also were given preorder/first-month bonus DLC in the form of Cherubimon Vice and Beelzemon Blast Mode. The pre-order bonus is still available in form of the European digital edition.
- Role Reprise:
- The Other Darrin: Almost all of the Royal Knights have gotten new Seiyuus in this installment, which is justified, as several incarnations of the Royal Knights or members of their species had been voiced by different seiyuus before.
- Chika Sakamoto and Mayumi Yamaguchi "reprise" their roles as Omegamon, but only because this Omegamon and his two decomposites Agumon and Gabumon are all based on their Digimon Adventure counterparts. Other incarnations of Omegamon/Omnimon have been played by three different seiyuus, (Hideyuki Tanaka in X-Evolution, Hiroki Takahashi in Savers, and Bin Shimada in Xros Wars).
- The most notable case is Yusei Oda who "replaces" Masako Nozawa, the latter having voiced three different and consecutive incarnations of Dukemon. Dukemon/Gallantmon's "screachy voice" description doesn't fit in line with Oda's performance, but it fits perfectly to Nozawa who isn't in the game.
- While Hiroko Emori voices Hackmon (and Jesmon) in this game, another Hackmon/Jesmon is later voiced by Shunsuke Takeuchi.
- Relationship Voice Actor: Takumi, Yuuko, Mirei, Rina and Reiko used to play an online game under the names Kirito, Yui, Sinon, Asuna and Leafa.
- Running the Asylum: A good number of people on Media Vision's staff are Digimon fans, and thus tended to implement their own ideas on how Digimon models would move and be presented (also leading to a large amount of influence from the anime, despite the game being disconnected in universe).
Trivia / Digimon Story: Cyber Sleuth