Accidentally-Correct Writing: Crim Hollingsworth, Scott Thompson's First Nations* but not really character, uses germ gel to get high. This was written as a loopy variant on the G-Rated Drug, but just as they were about to begin shooting, a news story came out about reservations actually having problems with people drinking germ gel. Keep in mind the gag had already been written in by this point.
Real Life Writes the Hairstyle: One of Scott Thompson's characters is bald because Thompson's own hair was falling out from the chemotherapy he was undergoing at the time for cancer, and he found wearing a wig all the time very uncomfortable.
Scott Thompson was undergoing chemo for stage one non-Hodgkin lymphoma during production. Dusty's baldness was really his own, and he only portrayed a few characters to keep his work load from getting too heavy. Also, two of them die. Thankfully, he's fine now.
Buttonhole the cat was inspired by Kevin McDonald's 20-year-old cat that required very, very costly vet bills to keep alive. The cat is also doing fine, if you take nature's side.