- Banned Episode: The What A Cartoon! Show pilot episode, "No Smoking" (due to claims of the short glamorizing tobacco use, even though "No Smoking" isn't considered an actual Cow and Chicken episode, as it aired on The What a Cartoon! Show) and the series episode "Buffalo Gals" (due to one letter complaining about the lesbian innuendo) have only aired once. Both episodes weren't even on the Netflix streaming version, but can be found on most video sites, like Veoh and YouTube.
- Bowdlerization: The episode "Comet" was edited in reruns to change Dad's line from, "Oh, divot!" (sounding almost like "Damn it!")note after hitting his golf ball and sending it flying to "Oh...two!" Since it started airing on Boomerang in America, the original line has been reinstated. The line was also uncut on the Netflix streaming version.
- Creator's Favorite: Charlie Adler has said that Cow was his favorite character to voice, with the Red Guy in close second.
- Cross-Dressing Voices: Charlie Adler as Cow. Most non-English dubs also have Cow's voice actor as a man doing a feminine voice. The only ones that don't are the dubs f.e. in Spain, Poland, Japan and Brazil.
- Edited for Syndication: In the summer of 1999, Cartoon Network split Cow and Chicken and I Am Weasel into separate shows, and thereafter, reruns of both shows were essentially a shuffle of three random segments in a half-hour, with "Buffalo Gals" replaced with "Orthodontic Police" and "Comet!" edited to redub "Oh, divot!" to "Oh...two!" Other episodes, like "Grizzly Beaver Safari" and "Chicken in the Bathroom" were pulled for reasons unknown (some say content; others say the episodes weren't good enough for the syndication package).
- Executive Meddling: After the first season was completed, David Feiss wanted to drop the I Am Weasel segments from the show altogether, but Cartoon Network demanded that he keep it in; eventually, a compromise was reached, that would allow Feiss to have Red Guy cross over into the Weasel segments, as to hold his interest in continuing the segment (and eventually, more characters, including Cow and Chicken themselves, were allowed to cross over into the Weasel segments).
- Keep Circulating the Tapes: The first two seasons of the show are available on DVD, but only if you live in Australia (and they're region-locked, so they can't play on just any DVD player). Only "The Cow With Four Eyes" and "Me an' My Dog" were ever released on DVD in the United States as part of special holiday DVD sets. Thailand was the only country ever to release all episodes (aside from Buffalo Gals) on DVD.
- Netflix did have the show on streaming, but...the way it's set up is weird and inconvenient. Rather than add new episodes to its stream, the season one episodes were soon replaced with season two episodes. And, before you ask, no, the Banned Episode "Buffalo Gals" was not included in the season two collection (though "Buffalo Gals" is available on online video and torrent sites, so it's not like it's gone forever, but it is a screw to the fans that not all of the episodes are included, especially those who've never seen "Buffalo Gals," but have heard of its notoriety and want to seek out the episode to see if Cartoon Network was right or wrong to ban it). On the plus side, the episode "Comet!" has Dad's original line as "Oh, divot!" instead of redubbing it as "Oh...two!" As of 2015, however, the show is no longer running on Netflix, which means seasons three and four will not be seen.
- Finally averted on August 2018 with the full series being made available for purchase on streaming platforms such as iTunes, Amazon and Vudu (minus the aforementioned "Buffalo Gals").
- The Other Darrin: Flem was primarily voiced by Howard Morris, but was instead voiced by Maurice LaMarche in the episode "Lost at Sea".
- Screwed by the Network: Somewhat. Before the final season had finished its initial run, Cartoon Network jumped the gun at splitting I Am Weasel into its own "spinoff". Because of this, the remaining "new episodes" of the series were essentially unaired "Cow and Chicken" segments cobbled together into half hour episodes.
- Talking to Himself: Charlie Adler voices a large amount of characters (Cow, Chicken, The Red Guy, I.R. Baboon, and some one-shot characters) who all interact with each other in any given episode. The most literal example of this is "Factory Follies," in which the Red Guy is actually talking to himself and is the only character in the episode with dialogue.
- What Could Have Been
- David Feiss originally wanted to use the idea, itself taken from a bedtime story he told his daughter, for a picture book. It would have had a softer art style and the title characters were friends rather than siblings. When Cartoon Network put out the call for pilot ideas, Feiss overhauled the book idea and turned it into the show we now have.
- "Buffalo Gals" originally had a scene in which Mom assured Dad that Cow should go with the Buffalo Gals because "...I rode with the Buffalo Gals when I was in college." The censors had the scene cut, though, in the end, that decision was a fool's errand as the entire episode ended up being banned.
- Working Title: "Comet!" was originally called "Dad's Ball" (and was most likely changed because of the censors).
- Similarly, "Pirate Lessons" was originally "Captain Butz Pirate" and "The Exchange Stüdent" was "The Holy Cheese War."
- Write Who You Know: David Feiss based the title duo's personalities and relationship on his two children.
Trivia / Cow and Chicken