- The Danza: Ed Helms as Dr. Ed Helms, forming half of Those Two Guys.
- Directed by Cast Member: Rob Cordry, Ken Marino and Lake Bell have all directed multiple episodes.
- Network to the Rescue: Adult Swim liked the show so much they financed and aired seasons 2+. It's now one of their top-rated programs.
- Shoot the Money: Lampshaded hard when they actually went to Brazil to shoot an outdoor scene and made a point of having the characters wander through areas that could only be in Rio.
Trivia / Childrens Hospital