It's no secret that the Big Show has acromegaly, the same condition that André the Giant suffered from. This is the reason for The Big Show's huge size. Unlike Andre however, he actually got treated for it.
Show is still embarrassed about WCW booking him as "Andre the Giant's son" in his early matches there, to the extent that to this day he still gets eager fans telling him how much they loved... his dad.
His run as a whole in WCW is this, as he hated the negative work environment as well as the constant back-and-forth backstage politics that made it difficult for him to work a match properly. Since he left for the WWF, he's been very vocal about his disgust working in WCW, even noting at one point that despite being WCW Champion for a year, he was being paid less than Hulk Hogan and other veteran talent who defected from WWF.
Show looks back negatively on his run in WWE's ECW brand, despite the fact that he's the only wrestler to hold the WWE Championship, WCW Championship and ECW Championshipnote Show noted in WWE Untold that he never wanted the championship to begin with, as he knew the ECW fanbase would disapprove of someone who had never wrestled in ECW at all holding the belt. He's especially embarrassed by his match against Batista at the Hammerstein Ballroom in New York, as he had to deal with the fans booing and heckling throughout the whole match.