In thisMelonpool strip, Mayberry FINALLY gets to watch the one episode of Star Trek he never saw.
"Phoenix Rising" is so far the only story arc in Sluggy Freelance that ends with Oasis in a healthy emotional state. While she does leave behind the friends she made in Podunkton to Walk The Earth, she's at least on good terms with them and seems to have gotten some peace of mind. Beats the hell out of her previous appearances, which all ended with her either Left for Dead or locked up in an insane asylum.
However it's recently been revealed that after she left all her friends bar the old martial artist have been kidnapped and locked up by hereti corp, the source of all her problems.
In Ansem Retort, Riku spends the whole strip being The Chew Toy to a degree that makes you feel the Emo Teen qualities are justified. Then Yuffie comes along. There are exactly two official couples (Zexion/anything female does not count) and he's now one of them. Enjoy your bone, doggie. She eventually dumps him. For his own Future Badass self.
In Homestuck, Tavros is almost certainly the greatest woobie in a whole species of woobies: he was cripped by Killer Game Master Vriska For the Evulz, rendering him in a wheelchair on a planet that includes mandatory tests of physical ability as a requirement to merely survive to reach childhood, and is mocked cruelly by Vriska afterwards by shooting down his attempts at self-confidence and creating for him a house full of stairs. And then Kanaya intervenes, persuading her to do something nice, and she alchemizes a rocket chair for him to realize his dream of flying. D'awww.
More recently, Dead!Tavros has recruited a literal army of ghosts for the final battle against Lord English. Vriska is astonished that Tavros has done something not only right but actually pretty awesome, which prompts Tavros to go into a "Suck It, Serket" dance for several strips. It only ends when Vriska agrees to acknowledge Tavros' achievement on the condition that he stop dancing.
The Order of the Stick: The Flumphs are recurring minor characters who get mistreated in about every one of their appearances, most often by serving as Living Crashpad for the main characters. Except for one time in Book 6, where they are left untouched while crossing the Dwarven lands, since technically they aren't trespassing because they're levitating and never touching the ground.
Flumph: Why can't more places we visit treat us this well?