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  • In season 2 of The Adventures of Figaro Pho, two middle-aged men, one short and skinny, one tall and fat, are recurring characters. They do lots of things together, from ballet dancing to ghost hunting.
  • Greg and Terry, the gay news anchormen from American Dad!.
  • In Asterix and the Vikings, Asterix and Obelix take this role, with Justforkix as the main character. This is particularly silly, since Asterix's name is in the title of the film, and Justforkix was only a (to be fair, strong and memorable) side character in Asterix and the Normans, the comic the movie is adapted from. One reviewer on Channel Awesome complained it was extremely strange since Asterix and Obelix are better-written, better-animated and designed, and easily the most interesting and likeable characters in the film, yet are relegated to backup for a whiny brat who gets no comeuppance.
  • The Badly Drawn Brothers from Avenger Penguins.
  • Beavis and Butt-Head is an entire show dedicated to this trope.
  • Code Lyoko:
    • The two School Newspaper Newshounds Milly and Tamiya.
    • Sissi's two cronies, Hervé and Nicolas.
    • Starting Season 3, Hiroki and Johnny also fit the mold.
  • Svatislav and Dimitri from Count Duckula.
  • Flem and Earl from Cow and Chicken.
  • Joey, Jeffy, and Jamie from Daria. They pretty much exist just to remind us that Quinn is attractive when she doesn't have a Boy Of The Week around to do it instead. In fact, they're SO Those Two Guys, Jamie is usually called something else, only to fruitlessly repeat that his name is Jamie.
  • Al and Moo Sleech from Doug.
  • Dragons: Riders of Berk: Mulch and Bucket, who also serve as Comic Relief with Mulch as the Straight Man.
  • The Fairly OddParents!:
    • Timmy's best friends Chester and A.J. who, true to form, get their own Rosencrantz and Guildenstern Are Dead-type episode.
    • Timmy's "back-up" friends, Sanjay and Elmer.
    • The rich jerks, Tad and Chad.
    • Juandissimo Magnifico and Cupid in later episodes.
  • Family Guy:
    • Brian and Stewie have played this role in episodes where they are the focus.
    • Cleveland and Quagmire fit Those Two Guys until Quagmire started getting his own episodes and Cleveland got his own show for a couple years before returning.
    • Tomik and Belgarde, the two blond guys from an unspecified region of Europe "who have been living in the United States almost long enough to sound American." It's is not clear who is Tomik and who is Belgarde, and it probably doesn't make a big difference.
  • Officers Smitty and URL in Futurama. They are both police cops who were partnered up with each other.
  • Sheen and Carl from Jimmy Neutron: Boy Genius and The Adventures of Jimmy Neutron, Boy Genius.
  • Johnny Test:
    • Mr. Black and Mr. White. They were revealed to be federal agents who are also mutants, but they have not used any of their powers in future episodes.
  • Al and Bob in The Jungle Bunch.
  • Stumpy and Quack Quack from Kaeloo.
  • Mertle Edmonds' posse in the Lilo & Stitch franchise, who mock Lilo with a drawn-out, sarcastic "Yeah!" Although they've been around since the original film, their names (Elena, Teresa and Yuki) weren't revealed until Lilo & Stitch: The Series.
  • The Lion Guard has Kiara's two friends, Tiifu and Zuri. The two are always seen together, usually with Kiara around as well.
  • Youngmee, Sue, and Jasper in Littlest Pet Shop (2012). Of these three, Youngmee gets preferential treatment by the writers by virtue of being neighbors with Blythe, the protagonist. And Youngmee becomes the only other human to know Blythe's ability to talk to animals.
  • Mr. Small and Mr. Nosy from The Mr. Men Show.
  • Brit and Tiff in My Life as a Teenage Robot. They’re pretty much inseparable and is almost always seen together.
  • My Little Pony: Friendship Is Magic:
    • It introduces Snips and Snails, a pair of excitable boy unicorns, in the episode "Boast Busters".
    • Lyra and Sweetie Drops were put side-by-side in the background often since their color-schemes complimented each other.
    • Twilight Sparkle and Spike have this chemistry at times, usually in episodes where they are supporting characters.
    • The show also occasionally likes to pair certain ponies together for particular episodes, even if these examples aren't nearly as consistent due to spotlight rotation. Rainbow Dash seems to form a good few of them (usually with Applejack or Fluttershy).
  • Stan and Koji from Ōban Star-Racers. They're mechanics, wisecrackers... and almost nothing else.
  • Phineas and Ferb:
    • Baljeet and Buford, with an interesting Friendly Enemy dynamic as well.
    • Major Monogram and Carl.
    • Sometimes, in episodes that focus on Candace, Perry or Doofenshmirtz, Phineas & Ferb themselves get demoted to this.
    • Two guys that remain minor from beginning to end on the show are the nameless husband and wife. They're in several episodes for the sole purpose of the same Running Gag. The wife will say, "I can't believe you bought a [fill-in-the-blank product] [fill-in-the-blank product rental/selling place] that didn't have any [fill-in-the-blank products]. What, did you think [fill-in-the-blank products] would just fall from the sky?" Then, the [fill-in-the-blank product] will indeed fall from the sky, usually landing on top of the wife.
  • Esther and Frank from Puppy Dog Pals
  • ReBoot:
    • Hack and Slash are this, particularly in the first two seasons.
  • Rocky and Bullwinkle have Edgar and Chauncey, two guys who occasionally comment on the action.
    Edgar: Now there's something you don't see every day, Chauncey.
Chauncey: What's that, Edgar?
Edgar: A [unusual sight].
Chauncey: I don't know, Edgar. [punchline]
  • The Simpsons:
    • Lenford "Lenny" Leonard and Carlton "Carl" Carlson. When the show spoofed Hamlet, these two were even cast as Rosencarl and Guildenlenny. And then they die five seconds after being named.
    • Sam and Larry, the other two patrons at Moe's. You know, the trucker with glasses and the bald guy in the orange jacket who (a) isn't Homer, and (b) looks either really depressed (like "about-to-cry-over-his-miserable-life" depressed) or really drunk. They [Larry and Sam] were around in the early episodes, but were quickly replaced by Lenny and Carl, so don't feel bad if you've been introduced to The Simpsons via the newer episodes and have never heard of either Larry or Sam. They still appear in the background at Moe's, but neither of them have had any lines in years.
    • Patty and Selma may come off as Those Two Twin Sisters. Especially in the early seasons they were hardly ever separated and sport similar hairstyles and wear similar clothes.
    • Eugene and Rusty, Springfield's "town perverts" from "Bart After Dark".
    • The cops Eddie (the cop who looks like an Off-Model Mr. Burns) and Lou (the black cop with the Popeye arms).
    • Bart's school friends from the first two seasons, Richard and Lewis.
    • Rod and Todd Flanders, the two sons of Ned Flanders. Hard to distinguish them from each other.
    • The twins Sherri and Terri.
  • South Park:
    • Craig and Clyde.
    • Token as he's oftentimes seen with Clyde and Craig. Plus the things that make him stand out (being rich and being black) are purely superficial, and he is otherwise the most normal kid.
  • Steven Universe:
    • Lars and Sadie, the pair of (not entirely platonic) Vitriolic Best Buds who run the Big Donut. Even outside of work, they are seen together most of the time. When Lars gets left behind on Homeworld, Sadie becomes angry and depressed, even quitting her job at the Big Donut because she feels so lonely working there without Lars.
    • In the present day, Blue and Yellow Diamond are almost never seen separately.
  • Stuart Little (animated series): Snowbell and Monty are the best of buddies in the series.
  • In the Teen Titans episode "Things Change", the girl who may or may not be Terra is flanked by two unnamed schoolgirls who seem to be her friends.
  • Several such pairs exist in Transformers: Animated: Blitzwing and Lugnut, Bumblebee and Bulkhead, and Mixmaster and Scrapper, and Snarl and Swoop. In the Transformers comics, Rack'n'Ruin of the Wreckers, who were bonded together in a desperate attempt to save their lives. The fact that they basically have one name (and it's never specified which is which), and that they receive basically zero characterization even as a pair makes them a perfect example.
  • Pete White and Master Billy Quizboy from The Venture Bros., who are also business partners and roommates in addition to being super-scientists. In fact, most of the series' characters are foils for one another; Doctor Venture and Brock, The Monarch and Dr. Girlfriend, Hank and Dean, Watch and Ward, Monarch Henchmen 21 and 24, etc. In DVD commentaries, Doc Hammer and Jackson Publick point this trope out and confess that this is because whenever they're stuck or bored while writing they just make up two characters who are basically each other and goof around doing voices as them.
  • Jody, Ophelia, and Roger are often demoted to Those Three Guys in The Life and Times of Juniper Lee. Then there's the two monsters who show up from time to time who invoke this trope.
  • Occasionally, Dooley and Clark in King of the Hill.
  • Yuzu and Nonki of Maryoku Yummy, so much so that the official site has one profile for the both of them.
  • Timon & Pumbaa.
  • Jean and Paul, the two gay inmates from Superjail!
  • VeggieTales:
    • Jimmy and Jerry Gourd.
    • Funny Foreigners Philippe and Jean-Claude, the French Peas.
  • KaBlam!:
    • Henry and June.
    • Sniz and Fondue.
  • Recess:
    • The Diggers (Sam and Dave).
    • King Bob's advisers, Jordan and Jerome.
  • Mervis and Dunglap from CatDog. They also count as the two only sane guys.
  • Whizzer and Dipstick in 101 Dalmatians: The Series
  • Larry and Steve from the first season of Rugrats.
  • Howie and Octo from Almost Naked Animals.
  • Slip and Slide from Coconut Fred's Fruit Salad Island.
  • Chip and Skip from Camp Lazlo, the two dung beetles who the role of The Ditz and are often seen as Edward's lackeys.
  • Rex and Starla from Napoleon Dynamite.
  • Sancho and Pedro from The Mysterious Cities of Gold.
  • Frizz and Nug from The Dreamstone. Rufus and Amberley occasionally act as this as well, depending on which side is getting the most Sympathetic P.O.V.
  • Total Drama:
    • Katie and Sadie.
    • Wayne and Raj.
  • Jang Keng and Tekirai from Hi Hi Puffy AmiYumi.
  • Meeker and Snerd on Bobby's World.
  • The Grim Adventures of Billy & Mandy have Grim and Mandy be this in episodes that focus on Billy.
  • Ren and Stimpy.
  • Marco's two loser friends Alfonzo and Ferguson from Star vs. the Forces of Evil.
  • Timmy and his teddy bear from Shaun the Sheep. Timmy and his mom also qualifies.
  • There are a few recurring duos (male and female) in Creature Comforts, though the ones who appear the most are the Slugs Gary and Nigel, and skip-dwelling Dogs Spanner and Trousers.
  • Memnock and Zenblock, the two alien virus warriors from Super Noobs. They further exaggerate this in their Bob and Rob disguises.
  • OK K.O.! Let's Be Heroes:
    • A Real Magic Skeleton and Brandon work at the frame store at Lakewood Plaza Turbo, and are usually seen together.
    • Nick Army and Joff the Shaolin Monk are two unlikely friends who are frequent customers at the Plaza.
  • The Magic Pudding: The Pudding Thieves.
  • In Ruby Gloom, conjoined brothers Frank and Len are always seen together, as it is impossible to only have one present at a time. There are also the characters of Mr. White and Mr. Whyte, two ghostly mob bosses, who are always shown together.
  • Miraculous Ladybug: Rose and Juleka as well as Max and Kim on occasion.
  • Infinity Train: One-One and Atticus have this sometimes.

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