- This is Older Than Steam, appearing in several of William Shakespeare's plays.
- The original pair is probably Rosencrantz and Guildenstern from Hamlet. They are unintentional evil minions. Hamlet has them killed anyway.
- Salarino and Solanio from The Merchant of Venice are similar, only with even less relevance to the plot. They also have so little individual personality that some actors refer to them as "the Salads".
- Cleomenes and Dion in The Winter's Tale.
- Romeo and Juliet has Benvolio and Mercutio. Slightly off, though; both are somewhat relevant to the story, and Mercutio dies midway through the story while Benvolio survives.
- The Tempest features Trinculo and Stephano. Played by Russell Brand and Alfred Molina in the 2010 film adaption.
- Most productions of Macbeth often turn Ross and Lennox (or Lennox and Angus, if Ross retains his considerably large role) into this, often merging said characters with the minor lords like Caithness, Menteith, and the unnamed lord (from III.vi) in the process.
- Sir Toby Belch and Sir Andrew Augueface, the two bumbling drunks from Twelfth Night, are the epitome of this trope.
- The later P.O.V. Sequel of Hamlet, Rosencrantz and Guildenstern Are Dead, subverts Those Two Guys. Rosencrantz and Guildenstern were inspired by Vladimir and Estragon (Waiting for Godot) and went on to inspire Jay and Silent Bob (The Askewniverse films) and even more recently and obviously, Rosenberg and Goldstein of the Harold and Kumar films and Timon and Pumbaa of The Lion King, who then get their own Rosencrantz and Guildenstern Are Dead in the form of the Direct-to-Video The Lion King 1 1/2.
- The smugglers are often played like this.
- Carmen's two friends, Mercedes and Frasquita.
- Ping, Pang and Pong in the opera Turandot.
- Colline and Schaunard in La Bohème.
- The Love of the Nightingale has two soldiers who represent Tereus' men.
- Sebastian and Bisque in The Rover
- Vladimir and Estragon in Waiting for Godot are a subversion of this trope, with Godot, the main character, never showing up.
- Bobchinsky and Dobchinsky from Nikolai Gogol's The Inspector General.
- Friedrich Dürrenmatt's Der Besuch der alten Dame has two creepy blind eunuchs refered to as die Beiden, which can be roughly translated with: Those Two Guys.
- Harry and Jamie, Alfred Doolittle's friends and fellow dustmen, from My Fair Lady.
Those Two Guys / Theater