- Tales of the Questor: Turns out two fae are sisters. One concedes it was not her sole motivation — but a big one.
- The Dreamland Chronicles:
- Bob and George:
- An epiphany for Megaman: Protoman is his brother -- he should treat him like it!
- George has to bring Bob along for this.
- Dr. Light complains about his selfish, ungrateful robot 'children' all the time, but he loves them all the same. Best shown in one Cataclysm short: Dr. Light complains about his bloody ungrateful robots at the start, but when Proto Man shows up after he's been fatally wounded, he tells him he's glad that one of his children outlived him.
- The Order of the Stick:
- Vaarsuvius objects to saving Julia on the ground they are on a world-saving quest, but when Roy points out how quickly they can do it, V agrees to help.Vaarsuvius: One's family must be defended when need arises.
- Haley's motive for the gold is to rescue her father. And she insists on Roy rescuing him against his wishes.
- When they learn of a different Draketooth, they realize that Girard Draketooth was so paranoid that he would have to use his family -- since he would trust no-one else.
- Elan has conflicted feelings about his Evil Twin Nale and his Archnemesis Dad Tarquin. Too bad for him that Nale is pretty set on killing him and even believes that this is how siblings should behave. His dad meanwhile thinks it would be awesome if Elan defeats him in an epic struggle someday. His eventual realization that his dreams are childish is a major piece of Character Development.
- Nale clearly believes that either this trope or Evil Is One Big, Happy Family will protect him from any insult to Tarquin. He's wrong. After Nale gloats about killing his father's friend and confidante Malack, Tarquin gives him one chance to fall into line, and when he refuses said olive branch, Tarquin unceremoniously kills him.
- Vaarsuvius objects to saving Julia on the ground they are on a world-saving quest, but when Roy points out how quickly they can do it, V agrees to help.
- Footloose: The final touch on the Wounded Gazelle Gambit.
- In Thistil Mistil Kistil: Loki thinks this means Coal's mother won't mind -- and learns that Coal does mind.
- In Squid Row, Grace lacks it, and it's lampshaded.
- In Wapsi Square, Jin's mother starts her defense with the observation that Jin is her daughter.
- In The Specialists, why Hartmann is willing to betray the Nazis: to protect his brother.
- In Our Little Adventure,
- In No Rest for the Wicked,
- In Dork Tower, Igor recommends ignoring genetic bonds of guilt and unfriending or unfollowing relatives.
- In Blue Yonder, Jared's driving motivation is to find and rescue his family.
- In Urban Underbrush, an attempt to invoke this — by pointing out he's been asked to side with a total stranger to make his own cousin uncomfortable — actually results in his enthusiastic cooperation.
- The official comics for Team Fortress 2 reveal that the Sniper was actually adopted, and his real parents live in New Zealand. When he finally meets them as an adult, he's thrilled to reconnect with them, completely ignoring that his parents are clearly selfish idiots that never cared for him even when he was still with them. The poor guy is still trying to help them even after they abandon him and his friends to their deaths twice.
- El Goonish Shive:
- Played straight with Elliot, whose first thought upon seeing his newly-created Opposite-Sex Clone was "She's family; help her." Ellen later echoes this sentiment.
- Defied by Susan, whose sour experiences with her family have lead her to declare "There is more to family than blood. No one is obligated to another by genetics alone!" She still agrees to meet with Diane, who may or may not be her half-sister, but makes it clear that she's not doing it just because they might be related.
Thicker Than Water / Webcomics