- Great Lakes Avengers:
- Mr. Immortal. His one power is the ability to come back from the dead after a few minutes. Since he has a considerable lack of fighting skills, this mostly translates to him frequently dying in a variety of hilariously painful and bizarre ways. Death by giant novelty scissors, death by impalement from a remote control, death by alcohol poisoning from a ray that was only supposed to make him drunk...
- An interesting variation in the succession of Grasshoppers that join the same team; none of them are the same character, but all of them take the hero name Grasshopper, join the team to replace the last Grasshopper, and then get killed in various ugly ways, each with less panel time than the one before.
- The MAD Magazine comic Spy vs. Spy features a black and a white spy trying to outsmart each other, and either one of them usually ends up beaten or dead by the end of the strip, only to be alive and well by the next gag. (There is also a sub-set of Spy vs. Spy vs. Spy strips which generally end with both the black and the white spy being dead, outwitted by the (female) grey spy.) According to Word of God from creator Antonio Prohías, they are not the same spy, but are instead merely spies from rival nations that die horribly and are replaced — this was the basis of his commentary on the Cold War.
- The Red Tornado gets blown up so many times it's become a running gag in the Justice League, and also makes its way into Batman: The Brave and the Bold.
- Similarly, the android Avenger The Vision gets killed / destroyed and then rebuilt all the time, although sometimes he comes back wrong, and it takes a few years for Status Quo Is God to bring him completely back to normal.
- Emperor Palpatine in Dark Empire. Practically everyone kills him. Mostly Luke and Leia. Han kills him the last time.
- Due to a combination of Black Comedy and Negative Continuity, nearly the entire cast of Twisted Toyfare Theatre, or at least the setting Megoville, dies several times over the course of the series. The character guides in the trades frequently list several deaths for each character. Bucky probably dies the most consistently.
- It's well known among Transformers fans that any character without a toy is a Red Shirt. The Transformers Armada comic series had a recurring Red Shirt in Dropshot, whose design was taken from a Japanese transforming robot that was not imported during the original series' run.
- Optimus Prime is probably the most infamous for this; it's often noted by fans that he dies at least once per series. Sometimes this is justified by them being different continuities, but in long-running stories, he's died multiple times. To whit, he died three times in both versions of the Marvel comic continuity, and three times in the original cartoon as well. Add on the various Japanese continuations of the cartoon, and that number goes up to six. He's mortally wounded again in Beast Wars, and his Spiritual Successor Primal dies another three times. It's noted in one series that one symptom of "primus apotheosis" (a disorder that causes a person to become an obsessive Hero-Worshipper of Optimus) is becoming convinced that you have to die in as impressive a manner as possible.
- The Decepticon Dirge is in any number of unconnected comic series, and meets his doom in nearly every last one, and blows up twice in the G1 cartoon. His death count may be higher than Prime. The TF Wiki quotes his Badass Boast, "Death comes to he who crosses me!" and attributes it to "a confused Dirge." However, this is eventually averted in The Transformers: Robots in Disguise, which is one of the few series (possibly only) where he survives several potentially lethal incidents (even far outliving his usual buddies Ramjet and Thrust) and becomes an important recurring character, only finally biting it in a Heroic Sacrifice in The Transformers: Unicron.
- The Decepticon Quake is also fairly death prone.
- All the Seacons are fairly susceptible to this, having died across multiple continuities, but among them, poor Nautilator easily takes the cake.
- One of the comic series plays with Optimus' tendency to bite it (see the Western Animation folder) by titling a special issue The Death of Optimus Prime. For once, it's metaphorical; Optimus is freed from the burden of leadership and declares That Man Is Dead, returning to his original identity of Orion Pax. That wouldn't take either, as he would return to action as Optimus Prime three years later.
- Challenge Of The Go Bots villain Cy-Kill had a habit of appearing as a dead Red Shirt in various stories, as a nod to their old Dueling Shows status. This persisted until writers realized that repeatedly murdering a character from an inoffensive and long-gone franchise was more mean-spirited than funny.
- DC's Solomon Grundy is a cursed zombie (sort of), so whenever he dies, he just rises again from the same swamp he died in (often with a completely new personality, including some times where he's been heroic), which of course happens all the time. Eventually they just strand him on an uninhabited planet.
- A number of characters in Viz have died and come back without explanation, but Suicidal Sid and Big Vern (and his supporting cast) die almost every time.
- The Finnish western comic, Pekkos Bill, have the titular hero dying violently in every third panel, always with the same smug expression on his face (unless the death involves the obliteration of his head or entire person).
- Iznogoud, in his plots to overthrow the Caliph, always ends up locked in a dungeon, permanently transformed, vanished, etc. and is back to resume his plotting at the beginning of the next episode.
- Freddy in Horndog.
- In The Sandman, the Dream's retinue includes Cain and Abel. Since they are technically an Anthropomorphic Personification of the idea of fratricide, Cain kills Abel almost every time they appear in the comic, in various ways (most infamously, mincing him into sausages as part of a stage performance for the visiting gods.)
- Uncle Festus in The Bojeffries Saga is ridiculously vulnerable to all the standard vampire weaknesses and constantly dies in ludicrous ways as a result. Fortunately, blood always seems to end up falling on his ashes, resurrecting him.
- Given Optimus Prime's track record in this department (See Western Animation below), it was natural this would happen in The Transformers, along with its sequel series Transformers: Generation 2. Optimus dies three times, the first time he's killed over a video game, the second time to destroying Unicron, and the third time to expose the light of the Matrix to the Swarm, from which he recovers almost instantly. That's not counting the alternate future of the UK comics, where he dies as he did in Transformers: The Movie, or in Regeneration One, where he's possessed by the corrupted Matrix, and then sort of dies. Of course, none of these are actually played for laughs, but... it's Optimus Prime. He's not going to stay dead.
- Multiple Man of the X-Men can fulfill this trope, for obvious reasons.
- The Metal Men used to get destroyed at the end of every story, and then Doc Magnus would fix them. They have a better survival rate these days.
- Pepe Cortisona in Condorito, as is the most hated character most of the jokes he's in end with his death. The comic has absolute Negative Continuity and every joke is more or less self-contain so his death is always temporary.
They Killed Kenny Again / Comic Books