- Unlike the other actors from the original Alien, including Sigourney Weaver, Ian Holm didn't return for Alien: Isolation, so he's replaced by Dave B. Mitchell. The only other exception is John Hurt as Kane but then again, the content relating to the original film takes place after his character's death.
- The audiobook versions of Alien: Out of the Shadows and William Gibson's script for Alien³ had Laurel Lefkow replace Sigourney Weaver as Ripley. Out of the Shadows also had Rutger Hauer replace Ian Holm as Ash, and River of Pain (the sequel to Shadows) and the adaptation of Gibson's script had Mairead Doherty replace Carrie Henn as Newt.
- Batman: Arkham Series:
- In Batman: Arkham City, Tara Strong replaces Arleen Sorkin as the voice of Harley Quinn, David Kaye replaces Tom Kane as Commissioner Gordon, and Grey DeLisle replaces Tasia Valenza as Martha Wayne. The latter two are puzzling, considering Kane and Valenza did return to reprise the respective roles of Quincy Sharp and Poison Ivy.
- To reflect its status as a prequel, Batman: Arkham Origins sees Roger Craig Smith and Troy Baker as the younger versions of Batman and the Joker respectively, as opposed to getting Kevin Conroy and Mark Hamill back. Similarly, JB Blanc replaces Fred Tatasciore as Bane, Brian Bloom replaces Nolan North as Black Mask, and Khary Payton replaces Steve Blum as Killer Croc. As with the recasting Gordon and Martha Wayne, the recastings of Black Mask, Killer Croc, and Bane are surprising, considering North returned to reprise the role of the Penguin, and Tatasciore and Blum returned to provide other voices. Speaking of Gordon, he's recast yet again, this time with Michael J. Gough voicing him, who ironically, despite voicing a younger version of Gordon, is older than both Kane and Kaye. Simiarly, Kelsey Lansdowne replaces Kimberly Brooks as pre-Batgirl/Oracle Barbara Gordon and Dick Grayson as Robin is voiced by Josh Keaton as opposed to Troy Bakernote .
- The tie-in film, Batman: Assault on Arkham sees Hynden Walch as Harley (who first voiced the character on The Batman), replacing both Sorkin and Strong; Neal McDonough replace Chris Cox as Deadshot, despite Cox being present; and Matthew Gray Gubler replace Wally Wingert as the Riddler. Cox himself is the fourth person to voice Commissioner Gordon, and many characters appear, but don't speak, having their grunts done by other people, including John DiMaggio (Killer Shark) filling in for Tatascoire and Blanc as Bane, Jennifer Hale (Killer Frost) filling in for Tasia Valenza as Poison Ivy, and Christian Lanz (who voiced Bird in Arkham Origins) as the Scarecrow.
- Batman: Arkham Knight sees John Noble replaces Dino Andrade and Christian Lanz as the Scarecrow. Jonathan Banks is Commissioner Gordon, making the fifth voice actor the present day version of the character has had in the Arkhamversenote . Likewise, Ashley Greene voices Batgirl/Oracle as opposed to Kimberly Brooks or Kelsey Lansdowne, Nightwing is voiced by Scott Porter as opposed to Troy Baker or Josh Keaton, and despite Baker coming back as Two-Face and the titular Arkham Knight, Matthew Mercer replaced him as the Tim Drake Robin. However, The Original Darrin is also in effect as the game does see the return of Tara Strong as Harley, Tasia Valenza as Poison Ivy, Wally Wingert as the Riddler, Mark Hamill as the Joker, and Steve Blum as Croc.
- Batman: Arkham VR sees Tom Austin replace Baker and Mercer as Tim Drake, Hugh Frasier replace Martin Jarvis as Alfred, Ian Redford replace Nolan North as the Penguin, and Jules de Jongh replace Grey DeLisle as Vicki Vale.
- Batman: Arkham Underworld sees the reuse of Harley's Asylum design and the designs of Bane and Killer Croc from that game and City—yet Tara Strong, Khary Payton, and J.B. Blanc reprise the respective roles, as opposed to Arleen Sorkin, Steve Blum, and Fred Tatasciore. Additionally, The Original Darrin is in play for the Scarecrow and Deadshot, being respectively reprised by Dino Andrade and Chris Cox.
- Suicide Squad: Kill the Justice League, set in the same universe, sees Samoa Joe replace John DiMaggio from Assault on Arkham as King Shark.
- Beast Wars: Transformers did not have any of the voice cast from the Beast Wars cartoon reprise their roles, nor were any of the game's voice actors identified.
- Beast Wars: Transmetals actually did get a sizeable number of the cartoon's cast to reprise their roles, but there are still some notable instances of characters getting different voice actors.
- Martin Roach replaces Blu Mankuma as Tigatron and Lee Tockar as Ravage in both versions of the game, in addition to replacing Doug Parker as Starscream in the Nintendo 64 version.
- Alec Willows replaces Richard Newman as the voice of Rhinox in the PlayStation version.
- Janet-Laine Green replaces Venus Terzo as the voice of Blackarachnia and Pauline Newstone as the voice of Airazor.
- Ian James Corlett replaces Colin Murdoch as the voice of Quickstrike in the PlayStation version.
- Cartoon Network: Punch Time Explosion's original Nintendo 3DS release gave most of the characters different voice actors from the ones who originally played the characters in their respective series. To appease the resulting backlash, the updated XL version for PlayStation 3, Xbox 360, and Wii recast most, but not all, characters with their original voice actors.
- Yuri Lowenthal replaces Thurop Van Orman as Flapjack, Benjamin Diskin as Numbuh One, David Coburn as Captain Planet, and Greg Cipes as Kevin Levin.
- Grey DeLisle voices Mac instead of Sean Marquette, Blossom instead of Cathy Cavadini, and Buttercup instead of Elizabeth Daily.
- Tara Strong replaces Candi Milo as the voice of Cheese and Dexternote , Nicky Jones as the voice of Chowder, and Ashley Johnson as the voice of Gwen Tennysonnote .
- Neil Kaplan replaces Greg Eagles as the voice of Grim and Jeff Bennett as the voice of Johnny Bravo.
- Fred Tatasciore replaces James Remar as Vilgax, Dee Bradley Baker as Ultimate Humongosaur, and the late Mako as Aku.
- Keith Ferguson replaces Phil LaMarr as Samurai Jack.
- Nolan North replaces Brian Doyle-Murray as Captain K'nuckles, Maurice LaMarche as Father, Roger L. Jackson as Mojo Jojo, Diedrich Bader as Hoss Delgado, and Dana Snyder as Gazpacho.
- Quinton Flynn replaces Richard Steven Horvitz as Billy and Dee Bradley Baker as the Toiletnator.
- The first Diamond Brothers book, "The Falcon's Malteser", was adapted as a film in 1988; a follow-up TV series simply called "The Diamond Brothers" (using an original story not based on one of the other books, although it was later novelised) was produced in 1991. Dursley McLinden and Colin Dale returned as Tim and Nick Diamond for the series, but Snape and Boyle were played by Bill Paterson and Jimmy Nail in the film and Michael Feast and Gordon Winter in the series. Feast and Winter were clearly cast, at least in part, because they bore more than a passing resemblance to Paterson and Nail.
- Disney Infinity:
- Several of the characters were not able to get their original actors to play them. For the most part, the replacement voice actors give very good and uncanny performances emulating the voices of the characters. However, some of them manage to sound a little off. The voice actors for Sulley, Captain Jack Sparrow and Ralph are some of the biggest offenders.
- Disney Infinity 2.0 has this, too.
- Despite being based on the Ultimate Spider-Man and Avengers Assemble cartoons, the Spider-Man and Avengers sets see Nick Fury voiced by Samuel L. Jackson, the original inspiration for the Ultimate Marvel version of Fury and the man who plays him in the Marvel Cinematic Universe, instead of Chi McBride, who voices him on the shows.
- However, as the inverse of the example with Jackson, despite being based on the Guardians of the Galaxy movie, the GotG set features many of the voice actors who voiced the characters on Ultimate and Assemble, as well as Hulk and the Agents of S.M.A.S.H., as opposed to the actors who played them in the movie, including Chris Cox as Star-Lord, Nika Futterman as Gamora, David Sobolov as Drax, Kevin Michael Richardson as Groot, James C. Mathis III as Ronan the Accuser, and Jeff Bennett as the Collector. The only exceptions regarding voice talent coming from the recent Marvel cartoons are Nolan North as Rocket (and even then, it's a reprise as he voiced Movie!Rocket in Marvel Heroes), Chris Edgerly as Yondu, and Carlos Alazraqui as Cosmo (the last of whom didn't even speak in the movie). But none of the actors from the movie reprised their roles.
- Courtnee Draper replaces Caitlyn Taylor Love as White Tiger.
- Despite voicing the Green Goblin before, Nolan North is this to Steven Weber as the Green Goblin, given the Goblin North voiced before was the classic Goblin and again, the Spider-Man playset in based on the Ultimate Spider-Man cartoon.
- Kyle Hebert voices J. Jonah Jameson instead of J. K. Simmons.
- Al Pacino did not allow EA to use his likeness or voice for The Godfather game, so Michael Corleone's appearance and voice were replaced.
- The tie-in games to Fantastic Four (2005):
- The first game saw Cree Summer fill in for Kerry Washington as Alicia. Additionally, the game had three bonus levels using the 616 and Ultimates costumes, where none of the film actors reprised their roles, including Robin Atkin Downes replacing Ioan Gruffudd as Reed, Grey DeLisle replacing Jessica Alba as Sue, Fred Tatasciore replacing Michael Chiklis as Ben, Quinton Flynn reprising his role from the '90s cartoon and replacing Chris Evans as Johnny, and Jim Meskimen replacing Julian McMahon as Dr. Doom.
- None of the actors from the film reprised their roles in the Fantastic Four: Rise of the Silver Surfer game.
- None of the voice actors from the Injustice games are returning to their roles for Injustice (2021). Among the recastings are Justin Hartley replacing George Newbern as Superman, Anson Mount replacing Kevin Conroy as Batman, Janet Varney replacing Susan Eisenberg as Wonder Woman, and Kevin Pollak replacing Richard Epcar as the Joker. Even the two voice actors from the games who do return (Fred Tatasciore, who voiced Bane and Solomon Grundy, and Laura Bailey, who voiced Supergirl) voice different characters (Tatascoire voicing Captain Atom and Bailey voicing Lois Lane and Rama Kushna).
- Lilo & Stitch franchise:
- Stitch!: Almost none of the original English voice cast from the Lilo & Stitch movies and Lilo & Stitch: The Series such as Chris Sanders, Daveigh Chase, Kevin Michael Richardson, Frank Welker or Rob Paulsen reprise their roles for the English dub; only Rocky McMurray reprised his role as Experiment 150/Clyde for that character's only appearance in the anime. Ben Diskin replaced Sanders as Stitch, while Jess Winfield, one of the executive producers and writers of The Series, provided the voice of Dr. Jumba Jookiba instead of David Ogden Stiers. Averted in the original Japanese version, where everybody else returns from the Japanese dub of the Lilo & Stitch franchise.
- Stitch & Ai: Once again, none of the original cast from the films or The Series return to reprise their roles, although Diskin and Winfield reprise their roles as Stitch and Jumba, respectively. Winfield has also now taken over the role of Jumba entirely after the death of David Ogden Stiers in 2018.
- The Madagascar video games based on the films also see plenty of replacements:
- Alex is voiced by Ben Stiller in the movies, but the video games have him voiced by Wally Wingert (the first game) and Crispin Freeman (the second and third game).
- Marty is voiced by Chris Rock in the movies and Phil LaMarr in the video games.
- Melman is voiced by David Schwimmer in the movies and Stephen Stanton in the video games.
- Bettina Bush replaces Jada Pinkett Smith as Gloria.
- Rico is voiced by Fred Tatasciore in the second video game instead of his regular actor John DiMaggio.
- King Julien is voiced by Keith Ferguson in the first video game and by his TV actor Danny Jacobs in the second and third game. Both replace Sacha Baron Cohen.
- Maurice is voiced by John Cothran Jr. in the first game and by Fred Tatasciore in the two games after. Both replace Cedric the Entertainer (films) and Kevin Michael Richardson (cartoons).
- Mort is voiced by Dee Bradley Baker in the first game and Matt Nolan in the future games, instead of Andy Richter (his film and cartoon actor).
- The Madagascar 3 video game sees Julianne Buescher, Danny Jacobs, and Alanna Ubach replace Jessica Chastain, Martin Short, and Frances McDormand as Gia, Stefano, and Captain Dubois.
- The only people to reprise roles from the Mortal Kombat games for the Mortal Kombat Legends series are Patrick Seitz as Scorpion (doubling as The Original Darrin given he was replaced by Ron Yuan in Mortal Kombat 11), Dave B. Mitchell as Sektor, Matthew Mercer as Kurtis Stryker, technically Steve Blum as the Bi-Han Sub-Zero (as Mirror Matches in Injustice 2 and 11 had one of the Sub-Zeros be Bi-Han), and also technically Grey DeLisle-Griffin as Kitana (as she'd recorded grunts for the character in Mortal Kombat X). Everyone else was recast.note
- MultiVersus mainly uses either characters' original voice actors or voice actors at least known for voicing said characters, like Jeremy Shada and John DiMaggio reprising their roles as Finn and Jake or Kevin Conroy as Batman, and even the advertising of the game makes a point about the all-star cast: despite this however, certain characters receive new voices actors, that being Steven Universe (voiced by Daniel DiVenere instead of Zach Callison), Tom and Jerry (voiced by Eric Bauza, rather than Frank Welker or via archival recordings of William Hanna) and Wonder Woman (voiced by Abby Trott instead of Susan Eisenberg, notable as Superman and Batman's voice actors are reprised from the DC Animated Universe).
- In June 2022, Nickelodeon All-Star Brawl added voice acting. Some characters inevitably had to be recast:
- Alex Cazares replaces Christine Cavanaugh as Oblina.
- Jim Meskimen replaces Tim Curry as Nigel Thornberry.
- Dustin Sardella replaces Zach Tyler Eisen as Aang.
- Vivian Vencer replaces Jessie Flower as Toph Beifong.
- Abby Trott replaces Renae Jacobs as April O'Neil.
- David Kaye replaces Gary Owens as Powdered Toast Man.
- Power Rangers: Battle for the Grid sees Meghan Camarena replace Amy Jo Johnson as Kimberly Hart, and Carrie Keranen replace Barbara Goodson, the late Thuy Trang, and Erin Cahill respectively as Rita Repulsa, Trini Kwan and Jen Scott
- The PC and PlayStation 2 versions of Power Rangers: Super Legends featured voice acting, but none of the characters featured in the game are reprised by the actors who played them in their respective Power Rangers series.
- Brian Donovan voices Billy Cranston/the Blue Mighty Morphin' Ranger instead of David Yost.
- Yuri Lowenthal voices Jason Lee Scott/the Red Mighty Morphin' Ranger instead of Austin St. John and Sam/the Omega Ranger instead of Brett Stewart.
- David Lodge replaces Bruce Hopkins as the voice of Choobo and Mark Ferguson as the voice of Moltor.
- Nolan North replaces Kerrigan Mahan as the voice of Goldar and James MacLurcan as Mack Hartford/the Red Overdrive Ranger.
- Darryl Kurylo voices Will Aston/the Black Overdrive Ranger instead of Samuell Benta and Anubis Cruger/the Shadow Ranger instead of John Tui.
- Scott McShane voices Hunter Bradley/the Crimson Thunder Ranger instead of Adam Tuominen and Jack Landors/the Red SPD Ranger instead of Brandon Jay McLaren.
- Keith Ferguson replaces Reggie Rolle as Damon Henderson/the Green Galaxy Ranger and Jason Chan as Cameron Watanabe/the Green Samurai Ranger.
- Blake Bradley/the Navy Thunder Ranger is voiced by Kenn Michael instead of Jorgito Vargas, Jr.
- Icthior and Cole Evans/the Red Wild Force Ranger are both voiced by Wally Wingert instead of Jason Hoyte and Ricardo Medina, Jr. respectively.
- Steve Blum replaces Robert Axelrod as the voice of Lord Zedd and Phillip Andrew as Merrick Baliton/the Lunar Wolf Ranger.
- Kim Mai Guest replaces Amy Jo Johnson as Kimberly Ann Hart/the Pink Mighty Morphin' Ranger, Amy Miller as Trakeena, Sally Martin as Tori Hanson/the Blue Wind Ranger, and Monica May as Elizabeth Delgado/the Yellow SPD Ranger.
- Eric Artell replaces Danny Slavin as Leo Corbett/the Red Galaxy Ranger.
- Powerpuff Girls Z:
- Most of the voice actors from the Japanese-language dub of The Powerpuff Girls (1998) were recast. For example, Emiri Katou replaces Kaori Asoh as Blossom.
- Voice acting-wise, the English-language dub of the anime is currently the only installment in the The Powerpuff Girls franchise without any connection to the original 1998 show, with the voices recorded in Vancouver by The Ocean Group. However, Tara Strong did express interest in reprising her role of Bubbles for the dub, as unlikely as that is to happen.
- Scarface: The World Is Yours: Owing to the twenty-three year time gap between the game and the film, most of the characters from the latter had to be recast.
- Al Pacino could not reprise his role as Tony Montana as his voice had been altered by years of smoking, so he hand-picked André Sogliuzzo to do the voice acting, although the likeness remains Mr Pacino's. The difference in the voice is very difficult to notice. Sogliuzzo has since went on to voice the character again in a Scarface-themed character pack for PAYDAY 2.
- Paul Shenar had died six years after the release of the film, so Alejandro Sosa was recast with Robert Davi.
- This also happened with various supporting characters getting bigger names including James Woods as George Sheffield, Cheech Marin as Gaspar Gomez, Michael York is Jerry (Tony's banker), and Miguel Sandoval as Nacho Contreras.
- Robo Cop Rogue City sees Peter Weller as RoboCop as the only returning actor. This is due to a combination of the voice voicing for the other characters was done in the UK, Nancy Allen (Anne Lewis) retiring, and Robert DoQui (Sgt. Reed), Dan O'Herlihy (the Old Man), and Mario Machado (Casey Wong) all dying between RoboCop 3 and the making of the game.
- Sonic the Hedgehog (2020) and its sequel have the titular character voiced by Ben Schwartz rather than Roger Craig Smith like in the games.
- The sequel similarly features Knuckles the Echidna voiced by Idris Elba rather than Travis Willingham or Dave B. Mitchell.
- Averted with Tails, as Colleen O'Shaughnessey got to reprise her role as the two-tailed fox.
- However played straight with "Sonic Drone Home". While Ben Schwartz keeps his role as Sonic, Tails and Knuckles are now voiced by Alicyn Packard and Fred Tatasciore respectively.
- This is also the case in the Japanese dubs, where Sonic is voiced by Taishi Nakamura rather than Jun'ichi Kanemaru, and Knuckles is voiced by Subaru Kimura rather than Nobutoshi Canna. Like in the English version, Tails is an aversion, as Ryō Hirohashi gets to reprise her role too.
- Kōichi Yamadera replaces Kotarō Nakamuranote as Dr. Robotnik / Dr. Eggman, Yamadera being the usual go-to VA for Jim Carrey in Japanese.
- Sonic Prime, being made in Canada, will feature an all-Canadian voice cast, with Deven Mack darinning for Roger Craig Smith as Sonic.
- The games based on the Spider-Man Trilogy would see Tobey Maguire reprise his role as Spider-Man and the actors who played villains reprise their roles — in stuff they were villains in, as before the Spider-Man 3 game, future Spidey voice actor Josh Keaton filled in for James Franco as Harry Osborn and likewise, J. K. Simmons would only reprise his role as Jonah in that game, being voiced in the earlier games by Jay Gordon. Additionally, Kirsten Dunst would only reprise her role as Mary Jane in Spider-Man 2, being voiced in Spider-Man: The Movie and the third game by a different actress (including Kari Wahlgren in the third one) and Robbie, Betty Brant, Aunt May, Curt Connors, and Mendell Stromm being voiced by different voice actors period. Even within the game series, Robbie, Betty, Kraven, the Scorpion, the Rhino, and Dr. Connors would change voice actors.
- In the first Star Trek: Elite Force game, each of the main characters was voiced by their original actor from Star Trek: Voyager except Seven, who was voiced by Joan Buddenhagen. Then when the expansion pack was released, Jeri Ryan stepped in to provide Seven's voice, even going so far as to re-record all of Seven's lines from the original game so there wouldn't be an obvious change when going from original to expansion material.
- In Star Trek: DS9: The Fallen, most of the original cast is present to voice their characters, with the rather bizarre exception of Avery Brooks as Captain Sisko. Instead, Sisko is voiced by Kevin Michael Richardson.
- Star Trek Online has Cryptic going out of its way to try to obtain many of the original actors should a famed character be used in some way. So far, the only exception to this is the Guardian of Forver, who was voiced by the late James Doohan (TOS' Scotty). Whoever his new voice actor is, he's really Narmy.
- In 2015, it was revealed that Cryptic went SAG-certified and that the limited number of spaces for non-SAG members should be dedicated to other Star Trek alumni. This caused a number of voice actors, such as Gabriel Wolf (who voiced the Liberated Borg Gaius Selan) to be jettisoned out. The first person known to be replaced was Chancellor J'mpok, originally voiced by Jon St. John and now voiced by Liam McIntyre.
- In the Star Wars Prequel Trilogy, Temuera Morrison portrays and voices the Clone Troopers. In Star Wars: The Clone Wars, the clones were voiced by Dee Bradley Baker. Since then, the role(s) has traded off, with Morrison primarily portraying them in Live Action, while Baker continues to voice them in Animation.
- Bob Bergen is this to Mark Hamill when it comes to portraying Luke Skywalker in Star Wars Legends; he even voices Luke in the Robot Chicken parodies.
- Transformers Aligned Universe includes Transformers: Prime, its sequel Robots in Disguise, and Rescue Bots, RB's sequel series Rescue Bots Academy, and the video games Transformers: War for Cybertron and Fall of Cybertron, but the only thing amounting between voice actors continuing the roles between WfC/FoC and Prime/RB/RiD is Peter Cullen once again as Optimus Prime until RBA even replaced him, and even in the same series, there's been a few cases.
- Frank Welker reprises his iconic roles the original cartoon as Megatron and (for his single line in Prime and his appearances in Robots in Disguise) Soundwave, effectively replacing Fred Tatasciore and Isaac C. Singleton Jr., who voiced the respective roles in WfC and FoC. Jeffrey Combs and Kevin Michael Richardson also replace Tatasciore in the respective roles of Ratchet and The Nemesis/Typticon. However, Tatasciore found himself on the other end of this trope for Prime's tie-in game, filling in for Tony Todd as Dreadwing.
- Steve Blum was replaced by David Sobolov as Shockwave. He was also replaced in the role of Cliffjumper by Nolan North in Fall of Cybertron and on Prime by Dwayne Johnson in "Darkness Rising, Part 1" and Billy Brown in "Out of the Past". Much like Tatasciore, however, Blum finds himself on the other side of this as well, replacing Sam Riegel as Starscream in Prime.
- Sumalee Montano replaces Kari Wahlgren as Arcee.
- Crispin Freeman is replaced by Adam Baldwin as Breakdown in Prime and as Grimlock for Fall of Cybertron by Grimlock's G1 voice actor, Gregg Berger. Khary Payton also voices Grimlock in Robots in Disguise, but Word of God is that RiD!Grimlock isn't the same character as WfC/FoC!Grimlock.
- Bumblebee's voice box was destroyed between WfC and FoC and spends FoC, and most of Prime and Rescue Bots mute. However, when his voice box is restored, he goes from Johnny Yong Bosch to Will Friedle.
- Michael Ironside replaces Jamieson Price as Ultra Magnus.
- Prime's sequel, Robots in Disguise, also gets in on this, with Darren Criss replacing Travis Willingham as Sideswipe. Though because of the difference in personality, TFWiki.net does treat the two as separate characters. As with Blum in Prime proper and Tatasciore in Prime's tie-in game, Willingham finds himself on the other end, as well, replacing Tatasciore as Motormaster.
- Robots in Disguise sees Arif S. Kinchen replace Scott Whyte (WfC) and Troy Baker (FoC) as Jazz, despite Baker voicing Steeljaw. That said, as with Mr. Tatasciore and Mr. Blum, this goes both ways with Mr. Whyte as he replaced David Kaye as Hardshell in Transformers: Rise of the Dark Spark. RiD also sees Liam O'Brien replace Baker as Kickback, again despite Baker being in RiD, though because of the difference in personality, TFWiki.net does treat the two as separate characters. Like Willingham, O'Brien is on both ends, having been replaced as Cyclonus by Harry Lennix.
- For a case of this happening in the same series (outside of Cliffjumper going from Dwayne Johnson to Billy Brown in Prime), Rescue Bots sees Greg Ellis replace Tim Curry as Dr. Morocco in Season 2, due to Curry suffering a stroke. The same series saw Hayley originally voiced by Lacey Chabert instead of Danica McKellar.
- Transformers: Rescue Bots Academy uses non-union New York-based voice actors, resulting in none of the characters returning from the original Rescue Bots, Transformers Prime or the 2015 Robots in Disguise series having their original actors reprise their roles.
- Elan Garfias is replaced by Andy Zou as the voice of Cody Burns.
- Francine Greene is voiced by Kaitlin Becker instead of Daimond White.
- Paul Guyet replaces LeVar Burton as the voice of Dr. Ezra Greene, Jeff Bennett as the voice of Mayor Luskey and Steve Blum as the voice of Heatwave.
- Mr. Harrison and Bumblebee are both voiced by Jeremy Levy instead of D.C. Douglas and Will Friedle respectively.
- Todd Perlmutter replaces Jeffrey Combs as the voice of Ratchet, Shannon McKain as the voice of Jerry, Jeff Bennett as Huxley Prescott and Robbie Daymond as Myles.
- Instead of Khary Payton, Grimlock is voiced by Terrence Flint.
- Optimus Prime is not reprised by Peter Cullen and goes through two different voice actors, with Hiro Diaz voicing him in the series premiere and Jake Tillman voicing Optimus for the remainder of the series.
- Michael Hansen replaces Parvesh Cheena as the voice of Blades.
- Frank Cwiklik voices Chase instead of D.C. Douglas.
- Boulder's voice actor is Keyon Williams isntead of Imari Williams.
- Transformers: Devastation: While a number of the voice actors from the original cartoon perform Role Reprises, several characters have been recast due to unfortunate deaths, such as Wheeljack and Starscream (both originally voiced by Chris Latta) being played by Christopher Swindle and Scott Whyte. However, some still-living actors are absent (Corey Burton doesn't voice Shockwave), and in an odd example of the trope, roles originally played by returning cast members are now played by others (in the cartoon, Megatron, Soundwave, Rumble, Frenzy, Skywarp and Mixmaster were all played by Frank Welker, but other actors play those last four while Frank reprises the first two).
- Tsukihime: The Japanese voice cast for the anime were replaced by the Melty Blood voice cast for subsequent appearances (up until the death in 2015 of Miyu Matsuki, who played Hisui in Melty Blood, upon which the role returned to Hisui's anime voice actress, Yumi Kakazu). In turn, the Melty Blood cast were replaced by the Tsukihime remake's voice cast for subsequent appearances.
- View Master Batman Animated VR:
- In the years since they last voiced the characters, Arleen Sorkin and George Dzundza had retired, and Bob Hastings and Efrem Zimbalist Jr. had passed on. Thus the game sees that, like in Batman: Arkham City, Tara Strong replace Sorkin as Harley Quinn; Eric Bauza replace Dzundza as the Ventriloquist and Scarface; and Maurice LaMarche replace both Zimbalist and Hastings as Alfred and Commissioner Gordon respectively.
- While both John Glover and Paul Williams are still alive and active, LaMarche and Bauza also replace them in the respective roles of the Riddler and the Penguin. Andrea Romano also replaces Richard Moll as the Batcomputer.
- While Tara Strong did voice Batgirl during the TNBA era, this does see her voice Barbara in her B: TAS design, who originally in that era was voiced by Melissa Gilbert and the late Mary Kay Bergman.
- None of the voice actors who worked on the Viewtiful Joe video games reprised their roles for the English dub of the anime adaptation, albeit a few of them did return in other roles, like Kevin Michael Richardson, who originally voiced Hulk Davidson in the games, voiced the announcer in the anime.
- Young Justice:
- Rob Lowe originally voiced Captain Marvel, but had to bow out due to scheduling issues with his other series, Parks and Recreation. He was replaced by his younger brother Chad for the remainder of the series.
- Deathstroke was voiced by Wentworth Miller in his first appearance in the second season, but Miller was soon replaced by Fred Tatasciore.
- While Rocket was voiced by the actress Kittie in season 1 and in the season 2 episode "Satisfaction", Denise Bouette replaced her for "Intervention".
- George Eads voiced The Flash for most of the series, but was replaced by James Arnold Taylor from "Endgame" onward.
- The video game tie-in Young Justice: Legacy featured even more replacements: Jason Spisak replaced Logan Grove and Dave Franco in the respective role of Beast Boy and the Riddler, Cree Summer became the third actress to voice Rocket, Danica McKeller replaced Alyson Stoner in the role of Batgirl, Kevin Michael Richardson replace Dee Bradley Baker as Blockbuster, Eric Lopez replace Danny Trejo as Bane, Vanessa Marshall replaces Sarah Shahi as Killer Frost, and Jeff Bennett replace Alan Tudyk as Psimon.
- Outsiders saw most of the voice cast return (including many of the characters who were recast for Legacy undergoing The Original Darrin), but with six expections: Greg Cipes (in a Role Reprise) replaced Logan Grove (who joined the Navy) as Beast Boy, David Kaye replaced Miguel Ferrer (who'd died) as Vandal Savage, James Arnold Taylor replaced Tim Curry (who suffered a debilitating stroke) as G. Gordon Godfrey, Hynden Walch replaced Ariel Winter as Perdita, and Zehra Fazal replaced Kelly Hu and Danica McKellar in the respective roles of Lian Nguyen-Harper and Hawkwoman.
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