- CJ has a breakdown early in the LP due to the crazy shit that keeps happening to him in Los Santos. Starting as insomnia, he has a breakdown in the middle of traffic driving to Management Issues. The mission itself is reframed as an attempted murder suicide.
- As one might expect, Big Smoke's death. To really puncuate the point during his final moments, C.J. stops seeing him as a traitor and more as his friend as he once was and decides to stay with him during his final moments.
http://tvtropes.org/pmwiki/pmwiki.php/Tearjerker/GrandTheftAutoSanAndreasGroveStreet4Life
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