- The episode "Good Friends" of Weirdsister College. Enid shows up at Weirdsister and, while she and Milly have fun at first, it's soon apparent that they've gone in different directions. And in the end the girls both realise that they can never be friends in the way they were back at Cackle's. Truth in Television sadly, as many people outgrow the friends they had in school and lives head in different directions.
- 'Miss Cackle' going ballistic and locking Mildred in her room in the season 1 finale. Mildred gets dragged from the classroom by her ear, abuse yelled at her in the office and is confined to her room just after she's told she's expelled. Even Miss Hardbroom is shocked by this behaviour. The kicker is that this is triggered by Ethel pranking Mildred in class. It's made a little better since it's only Agatha Cackle impersonating her sister.
- The end of the first Halloween episode - as Ethel casts a spell on her broomstick to humiliate Mildred. It's slightly worse than in the book - where Mildred is bucked off and causes the other girls to fall off as well. Here it's only Mildred that gets humiliated and she crashes into the Grand Wizard. The book also only says that "even Maud was being very cool towards her friend" - but the TV series has Maud outright ignore Mildred after it happens.
- The end of "The Unfairground" when Jadu and Mildred are expelled from Cackle's. What makes this even sadder is that Miss Cackle still gives them a Pet the Dog moment - rather than have their permanent records ruined with an expulsion, she'll write a letter to their parents asking them to just withdraw them from the school.
- A minor one, but Beatrice Bunch seems so sad when she reveals that she's allergic to cats. Thankfully, Miss Cackle makes it better.
- In "The Worst Witch All at Sea", Miss Hardbroom gets knocked unconscious and stays that way all night. She's woken up the next morning, but will have to be in bed for the rest of the holiday, which is unpleasant, especially for someone like HB. Worse still, Mildred doesn't mind, in fact she's glad.
- In the 2017 series, Mildred suffers from a severe lack of self-esteem, constantly being belittled and suffering a series of accidents which make her look even worse, while doing her best to win any respect from her peers at all. When she finds out in the series 2 finale that she is descended from a witching family, she's overjoyed.
Tear Jerker / The Worst Witch