- Whenever Miss Machiko's class begs her not to leave.
- In "The July 7th Rendezvous", Kame's crush was leaving on the train at the end of the episode. He was to shy to face her at first but manages to give a heart-wrenching goodbye right before she leaves.
- Mr. Yamagata's mother leaving on sour terms in episode 60. He left Machiko's house ashamed and depressed before she comforted him.
- In "A Surprising Present From Santa" we meet a little girl who's sad that his father had to go away temporarily. She's been living on her own with only her pet dog to keep her company.
- The mother of another girl losing her child due to negligence in "Machiko the Lion Tamer". She made a poor choice, but she's clearly regretful.
Tear Jerker / Maicchingu Machiko-sensei